A marketing approval application for a generic drug submitted to the US Food and Drug Administration.
A class of drugs that is used to treat hypertension and other cardiovascular diseases, which work by blocking the production of a hormone called angiotensin II.
Acute Coronary Syndrome (ACS)
An umbrella term used to cover any group of clinical symptoms compatible with acute myocardial ischaemia.
Adenosine Diphosphate (ADP)
A molecule that plays an important role in energy transfer in cells.
An agent that modifi es the effect of other agents (for example drugs and vaccines) while having few if any direct effects when given by itself; it operates like a catalyst in chemical reactions.
Treatment given as an adjunct to another medical intervention, for example surgery.
American Depositary Receipt evidencing title to an ADS.
American Depositary Share representing one underlying Ordinary Share.
An unwanted, negative consequence associated with the use of a medicine.
A substance capable of binding to a molecular target to initiate or enhance a physiological reaction.
An allergic reaction to airborne substances such as pollen or dust.
A group of disorders causing deterioration of the brain, which affects one’s memory and reasoning capabilities.
The total or partial loss of sensation, especially in relation to pain.
The inability to feel pain whilst conscious.
Chest pain/discomfort caused by lack of oxygen to the heart muscles through reduced blood fl ow in the coronary arteries.
A physiological process in which new blood vessels grow from pre-existing vessels.
Angiotensin Converting Enzyme (ACE)
Converts a hormone called angiotensin to its activated form called angiotensin II, enabling it to function. Angiotensin II acts by narrowing the diameter of the blood vessels and thereby raises blood pressure.
A hormone that causes blood vessels to narrow and thereby raises blood pressure.
A degenerative inflammatory disease affecting the spine and causing chronic pain.
A substance capable of binding to a molecular target to neutralise or counteract a physiological reaction.
A drug that blocks the cellular uptake of testosterone by the prostate gland and used in the treatment of prostate cancer.
A drug for the treatment of depression or mania.
A drug that inhibits the enzyme, aromatase, which is involved in the production of
the female sex hormone, oestrogen and therefore is used in the treatment of breast cancer.
AstraZeneca or AstraZeneca Group
AstraZeneca PLC and its subsidiaries.
The progressive narrowing or hardening of the arteries linked to the build-up of
lipids (fats) in the arterial walls and the formation of atheromatous plaque.
A build up of cholesterol and fatty material in the walls of blood vessels as a consequence of atherosclerosis.
Atrial fibrillation (AF)
Abnormal irregular heart rhythm.
Atypical Anti-Psychotic Drugs
Second generation drugs to treat psychosis with reduced likelihood to cause movement disorders.
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