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Directors' shareholdings

The table below shows any change in the interests of the Directors (including the interests of their Connected Persons, as such term is defined in the Financial Services and Markets Act 2000) in Ordinary Shares from 1 January 2011 to 31 December 2011 or on the date of resignation of such Director (if earlier). All such interests were beneficial except as otherwise stated. However, interests in Ordinary Shares or ADSs that are the subject of PSP Share Awards, AZIP Share Awards and/or the Deferred Bonus Plan discussed in this Report, are not included in the table below but are shown in the Performance Share Plan, AstraZeneca Investment Plan and Deferred Bonus Plan tables from page 126. No Director or senior executive beneficially owns, or has options over, 1% or more of the issued share capital of the Company, nor do they have different voting rights from other shareholders. None of the Directors has a beneficial interest in the shares of any of the Company’s subsidiaries. Between 31 December 2011 and 2 February 2012, there was no change in the interests in Ordinary Shares shown in the table below.

NameBeneficial interest in Ordinary Shares at 1 January 2011 or (if later) appointment dateChange to beneficial interestBeneficial interest in Ordinary Shares at 31 December 2011 or (if earlier) resignation date
Louis Schweitzer 16,615 - 16,615
David Brennan 186,982 59,192 246,174
Simon Lowth 9,346 44,880 54,226
Bruce Burlington 553 - 553
Jean-Philippe Courtois 2,635 - 2,635
Jane Henney1 1,314 - 1,314
Michele Hooper 2,400 - 2,400
Rudy Markham 1,940 512 2,452
Nancy Rothwell 1,314 518 1,832
Shriti Vadera 3,000 - 3,000
John Varley 1,294 450 1,744
Marcus Wallenberg 63,646 - 63,646

1 Part-year only as ceased to be a Director on 28 April 2011