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Financial highlights 2011

Dividend for 2011

 $PenceSEKPayment date
First interim dividend 0.85 51.9 5.33 12 September 2010
Second interim dividend 1.95 123.6 13.21 19 March 2011
Total dividend 2.80  175.5 18.54  

 $2.55 Dividend per ordinary share 2010

Distributions to shareholders

 20112010200920082007
Dividend ($ million) 3,6781 3,342 2,977 2,739 2,641
Share re-purchases ($ million) 6,015 2,110 - 610 4,170

Our key products

In 2011, our top 10 medicines by sales were:

Atacand

$1,450m (-6%)

(2010: $1,483m; 2009: $1,436m)

for hypertension and heart failure

Crestor

$6,622m (+13%)

(2010: $5,691m; 2009: $4,502m)

for managing cholesterol levels

Nexium

$4,429m (-12%)

(2010: $4,969m; 2009: $4,959m)

for acid reflux

Losec/Prilosec

$946m (+11%)

(2010: $986m; 2009: $946m)

for the treatment of acid related diseases

Seloken/Toprol-XL

$986m (-20%)

(2010: $1,210m; 2009: $1,443m)

for hypertension, heart failure and angina

Seroquel IR

$4,338m (+3%)

(2010: $4,148m; 2009: $4,171m)

for schizophrenia and bipolar disorder

Seroquel XR

$1,490m (+27%)

(2010: $1,154m; 2009: $695m)

for schizophrenia, bipolar disorder and major depressive disorder

Symbicort

$3,148m (+20%)

(2010: $2,746m; 2009: $2,294m)

for asthma and chronic obstructive pulmonary disease

Synagis

$975m (-6%)

(2010: $1,038m; 2009: $1,082m)

for for RSV, a respiratory infection in infants

Zoladex

$1,179m (+3%)

(2010: $1,115m; 2009: $1,086m)

for prostate and breast cancer

A-Z list of products

Our pipeline

We have: 86 pipeline projects of which 79 are in the clinical phase of development and a further seven are approved or launched.
9 projects in late stage of clinical development, either in Phase III or under regulatory review.
18 out of 33 projects in phase II, III or under regulatory review sourced externally.

We continue to prioritise our resources and focus discovery activities on those diseases within our existing therapy areas where we believe there is the greatest potential to meet patient need through the application of novel science. This continual process of prioritisation is designed to ensure that the projects we have in our pipeline constitute the programmes which we believe are most likely to deliver technical and commercial success.
 

Research and Development

In 2011 we made a core investment of $5 billion on R&D.

At the end of 2011, our R&D organisation comprised approximately 11,300 people at 14 principal centres in eight countries.

Our R&D organisation continues to evolve to meet the challenges facing our industry by investing in high quality science and harnessing the innovation of our people. We are continuously improving our understanding of mechanisms and targets that will become the foundation for developing and delivering tomorrow’s new medicines. These efforts are undertaken with the highest ethical standards, as we are committed to delivering innovative medicines responsibly.
 

Our key financials

 $m 2011$m 2010$m 2009$m 2008$m 2007
Revenue 33,591 33,269 32,804 31,601 29,559
Core *          
Operating profit 13,167 13,603 13,621 10,958 9,411
Profit before tax 12,739 13,086 12,885 10,495 9,300
Earnings per share $7.28 $6.71 $6.32 $5.10 $4.38
Reported          
Operating profit 12,795 11,494 11,543 9,144 8,094
Profit before tax 12,367 10,977 10,807 8,681 7,983
Earnings per share $7.33 $5.60 $5.19 $4.20 $3.74
Net cash inflow from operating activities 7,821 10,680 11,739 8,742 7,510
Dividends paid (3,764) (3,361) (2,977) (2,739) (2,641)
Cash returned to shareholders 9,693 6,221 3,339 3,581 6,910

* Core financial measures are supplemental non-GAAP measures which management believe enhance understanding of the Company’s performance.