Predictive science

The right target, the right exposure, the right drug

Predictive science is the collective name for a network of scientific disciplines. It focuses on indicating the most likely effects and outcomes. By combining all the knowledge available to us and applying specialised technology, equipment and methods, such as modelling and simulation, we can better answer critical questions in the drug discovery and development process.

Predictive Science is mostly concerned with helping to provide critical insights about whether we have the right target, the right exposure, the right drug. The information obtained can help shape the design of experiments to follow in the next stage or inform an early decision not to proceed.

Success story

AZD8329 (diabetes)

AZD8329 is an oral, once daily inhibitor of the 11βHSD1 enzyme with best-in-class potential for the treatment of Type 2 diabetes. Using all available information, a preclinical in vitro model was developed to explore the mechanism of action. The results were used to predict what would happen in patients. This model was then used to design the dose-finding study. As a result of insight gained through modelling, the team was able to recommend reducing the proposed study size from 270 to 115 patients for the Phase IIb trial. This outcome resulted in lowering the cost of the study.

Ruth March, Head of Personalised Healthcare & Biomarkers, AstraZeneca

Ruth March, Head of Personalised Healthcare & Biomarkers, AstraZeneca

Ruth March, Head of Personalised Healthcare & Biomarkers, AstraZeneca

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Ruth March explains what drives her passion for working in personalised healthcare, why it is important for pharma and patients, how AstraZeneca is integrating this approach into its research and development and what benefit is already being delivered to patients in different disease areas.

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Ruth March explains what drives her passion for working in personalised healthcare, why it is important for pharma and patients, how AstraZeneca is integrating this approach into its research and development and what benefit is already being delivered to patients in different disease areas.