The combination of candesartan cilexetil-hydrochlorothiazide has been evaluated in 12 controlled clinical trials involving approximately 4,600 hypertensive patients. Overall, Atacand HCT was well tolerated, maintaining a blood pressure lowering effect over a full 24-hour period.
Despite the availability of numerous antihypertensive medications, controlling blood pressure in the hypertensive population remains a problem. Recent U. S. public health surveys suggest that only one in five people with hypertension have their blood pressure adequately controlled. To help improve this situation, physicians are turning to fixed-dose combination antihypertensives when desired blood pressure targets are not achieved on monotherapy. Atacand HCT offers dosing flexibility and effective blood pressure control for patients uncontrolled on a single agent.
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of ethical (prescription) pharmaceuticals and the supply of healthcare services. It is one of the top five pharmaceutical companies in the world with healthcare sales of $15 billion and leading positions in sales of gastrointestinal, oncology, anesthesia including pain management, cardiovascular, central nervous system (CNS) and respiratory products.
|
Steve Brown
+44 (0)20 7304 5033
Lucy Williams
+44 (0)20 7304 5034
|
|
|
- Angiotensin II receptor blocker (ARBs) work by inhibiting the effects of angiotensin II, a peptide that constricts blood vessels and leads to hypertension. Diuretics, such as hydrochlorothiazide, aid in reducing blood pressure by enhancing the ability of the kidneys to eliminate salt and fluid from the body. Atacand was launched in the U. S. in October 1998, and is available in 33 countries. The combination product was approved in 12 European countries in March and is marketed under the brand name, Atacand® Plus.
- Often referred to as the "silent killer", hypertension affects 50 million people in the United States and is responsible for more than 40,000 deaths annually, according to the American Heart Association. Uncontrolled hypertension has been linked to stroke, heart attack and heart failure. Although the cause of 90-95 percent of cases of hypertension is unknown, the disease can be controlled with medication.
|