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17 February 2003
RESULTS OF EXANTA™ (ximelagatran) TRIAL IN PREVENTION OF STROKE IN ATRIAL FIBRILLATION (SPORTIF III) TO BE PRESENTED AT ACC MEETING

AstraZeneca announced today that headline results of the recently completed SPORTIF III (Stroke Prevention Oral Thrombin Inhibitor in Atrial Fibrillation) trial comparing Exanta™ (ximelagatran), with warfarin, the current standard of care, are encouraging. The data support the emerging positive benefit / risk profile for Exanta in this indication and will be presented in the Late-Breaking Clinical Trial section of the American College of Cardiology (ACC) meeting in Chicago on 2 April 2003.

The Exanta regulatory submission for prevention of stroke in atrial fibrillation, which remains on track in Europe and the US, also includes SPORTIF V and other trials in the extensive clinical trial programme.

Exanta is set to be the first new fixed-dose oral anticoagulant since the introduction of warfarin over 50 years ago and is currently being investigated in an extensive clinical trials programme for a number of key indications.

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. It is one of the top five pharmaceutical companies in the world with healthcare sales of over $17.8 billion and leading positions in sales of gastrointestinal, oncology, anaesthesia (including pain management), cardiovascular, central nervous system (CNS) and respiratory products. AstraZeneca is listed in the Dow Jones Sustainability Index (Global and European) as well as the FTSE4Good Index.

Further enquires to:

Media Enquiries

Emily Denney
+44 (0)20 7304 5034

Steve Brown
+44 (0)20 7304 5033


Investor Relations

Mina Blair-Robinson
+44 (0)20 7304 5084

Jonathan Hunt
+44 (0)20 7304 5087


Exanta  is a trademark, property of the AstraZeneca group of companies.

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