Singapore

Singapore

At AstraZeneca, we share a common aim. To make our best contribution to the fight against disease by providing medicines that make the biggest possible difference in patient health.

We discover, develop, manufacture and market prescription medicines for six important areas of healthcare, including some of the world’s most serious illnesses: cancer, cardiovascular, gastrointestinal, infection, neuroscience, and respiratory and inflammation.

Medicines

Cardiovascular

Cardiovascular disease (CVD) is the world’s number one killer, more people die annually from CVDs than from any other cause. According to the WHO World Heath Report 2011, one in three deaths are caused by CVD1. Coronary Heart Disease (CHD) is the most significant type of CVD in terms of death and disability worldwide2. In 2011, heart disease accounted for 30.4% of all deaths in Singapore. Statistics published by the Singapore Heart Foundation show that heart disease claimed more than 5,480 Singaporean lives in 20113

 200920102011
Total No. Of Deaths 17,101 17,610 18,027
Total No. Of Deaths from Heart Disease 5,404 5,618 5,480
Total % 31.6% 31.9% 30.4%

CHD is typically caused by atherosclerosis1 of the coronary arteries. The coronary arteries are particularly vulnerable to atherosclerosis because they are small in diameter. If the coronary arteries are blocked for a prolonged length of time, parts of the heart muscle are deprived of oxygen and vital nutrients, which causes the affected area to die (myocardial infarction or heart attack).

In most cases, heart attack or severe chest pain (unstable angina) is also caused by a blood clot that reduced or blocked the flow of blood through an artery to the heart. Often, such blood clots are formed when atherosclerotic plaques rupture, causing blood platelets to clump together to form a blood clot. If a heart attack patient survives, he or she carries the risk of forming new blood clots in future, which may lead to another cardiovascular event. Oral antiplatelet agents, such as BRILINTATM work to lower this risk by preventing the platelets from clumping together.

Cardiovascular range:

  • Brilinta
  • Crestor
  • Atacand, Atacand Plus
  • Imdur
  • Niften
  • Plendil
  • Tenormin
  • Zestril

1. World Health Report 2002. World Health Organization. http://who.int
2. Murray CJL, Lopez AD. Mortality by cause for the eight regions of the world: Global Burden of Disease Study. Lancet 1997; 349: 1269-76
3. Statistics from the Singapore Heart Foundation: http://www.myheart.org.sg/?page_id=51
4. "Antiplatelet agents". American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=4438 Last accessed September 30 2010.

Gastrointestinal 

Gastroesophageal reflux disease (GERD) is a chronic, relapsing acid-peptic disorder characterized by recurrent troublesome reflux symptoms1. The prevalence of GERD in Asia as reported from symptom-based studies ranges from <1.6% to 20%2.

Gastrointestinal range:

  • Nexium
  • Losec

1. Vakil N et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am. J. Gastroenterol 2006; 101:1900-20.
2. Goh KL. Gastroesophageal reflux disease in Asia: A historical perspective and present challenges. J Gastroenterol Hepatol 2011; 26 (Suppl. 1): 2-10.

Respiratory

Some 235 million people suffer from asthma. It is the most common chronic disease among children1. Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the world2.

Respiratory range:

  • Symbicort
  • Pulmicort
  • Bambec
  • Rhinocort

1. World Health Organization. Chronic respiratory diseases. Available at http://www.who.int/respiratory/asthma/en. Accessed on Sept 9, 2013.
2. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. Updated 2013.

Rheumatology

Osteoarthritis (OA) refers to a clinical syndrome of joint pain accompanied by varying degrees of functional limitation and reduced quality of life. It is the most common form of arthritis and one o the leading causes of pain and disability worldwide. Knees, hips and small hand joints are most commonly affected.

Rheumatoid arthritis (RA) is an inflammatory disease. It typically affects the small joints of the hands and the feet, and usually both sides equally and symmetrically, although any joint can be affected1. It is a systemic disease and so can affect the whole body, including the heart, lungs and eyes2.

Rheumatology range:

  • Vimovo

1. The care and management of osteoarthritis in adults. NICE Clinical Guideline 59. Issued: February 2008.
2. The management of rheumatoid arthritis in adults. NICE Clinical Guideline 79. Issued: February 2009, modified August 2013.

Infection

Drug resistance is becoming more severe and many infections are no longer easily cured, leading to prolonged and expensive treatment and greater risk of death. Recognising the severity of this problem, the World Health Organization (WHO) selected “Combat Drug Resistance” as the theme for World Health Day 2011, calling for urgent action to safeguard drug treatments.

Infection range:

  • Zinforo
  • Meronem
  • Cubicin

1. World Health Day 2011. Urgent action necessary to safeguard drug treatments. Available at http://www.who.int/mediacentre/news/releases/2011/whd_20110406/en/index.html. Accessed on Sept 9, 2013.

Oncology

Humans are made up of cells. Within each cell are genes which direct and control all the cell's functions and determine how and when it divides and grows. Normal cells divide and grow at a controlled rate. How fast or slow a cell divides and grows, and what function it does, depends on the gene within that cell. Cancer begins as a change in the gene of a single normal cell in any part of the body. Once this change takes place, the set of instructions in the gene is changed and the cell no longer acts like it normally does. "Cancer" is actually due to the accumulation of many such errors.(i)

Lung cancer and breast cancer are the top most frequent cause of cancer deaths amongst men and women in Singapore respectively (ii)

Oncology range:

  • Iressa
  • Zoladex
  • Faslodex
  • Arimidex
  • Casodex
  • Nolvadex

(I) & (ii) National Cancer Centre Singapore. Retrieved from http://www.nccs.com.sg . Last accessed 4 October 2013.

Central Nervous System

It is estimated that around 450 million people worldwide have a mental health problem. In Singapore, neuropsychiatric disorders are estimated to contribute to 24.4% of the global burden of disease (WHO, 2008).

Central Nervous System range:

  • Seroquel XR
  • Seroquel

Anaesthesia range

  • Emla
  • Marcain
  • Naropin
  • Xylocaine

SG_NoBrands_81,515.022_07/03/2014

Adverse event reporting

AstraZeneca Singapore Pte Ltd
8 Wilkie Road #06-01 Wilkie Edge Singapore 228095
General phone line: +65 6579 6500
General fax line: +65 6238 7815
Medical information: medinfo.mysg@astrazeneca.com
AE report: patient_safety@astrazeneca.com
 

Careers

Interested in joining us?

Build a Career with Us

We look for people who share our thirst for knowledge, our love of innovation and our ambitious approach to self-improvement. If that’s you, why not discover everything that makes us the destination of choice for some of the brightest people in the global biopharmaceutical industry?

The diverse cultures, backgrounds, skills and experience of our global workforce bring great creative strength and energy to our business and have a critical role to play in achieving our strategic objectives. Understanding the different needs and perspectives of our stakeholders is central to how we do business and ultimately how we create medicines that society values. So it is vital that the diversity of the communities we serve is reflected in our workforce and our leadership teams, locally and globally. An inclusive culture where diverse talents can flourish is also critical to attracting and retaining the best people in the right places to take our business forward.

Our dedicated training and development plans consider your needs and are supported by a variety of education and on-the-job training programs to help you get the most out of your career.

More importantly, you’ll have access to ongoing support from your manager, helping you to set and achieve your individual career goals.

If you are interested to build a career with us , you can send your resume to:

AstraZeneca Singapore Pte Ltd
8 Wilkie Road #06-01 Wilkie Edge Singapore 228095
General phone line: +65 6579 6500
General fax line: +65 6238 7815
Email: hr.sg@astrazeneca.com

AstraZeneca Singapore Pte Ltd

8 Wilkie Road#06-01 Wilkie EdgeSingapore228095+65 6579 6500+65 6238 7815http://www.astrazeneca.com/singapore