At AstraZeneca, we share a common aim. To make our best contribution to the fight against disease by providing medicines that make the biggest possible difference in patient health.
We discover, develop, manufacture and market prescription medicines for six important areas of healthcare, including some of the world’s most serious illnesses: cancer, cardiovascular, gastrointestinal, infection, neuroscience, and respiratory and inflammation.
Cardiovascular disease (CVD) is the world’s number one killer, more people die annually from CVDs than from any other cause. According to the WHO World Heath Report 2011, one in three deaths are caused by CVD1. Coronary Heart Disease (CHD) is the most significant type of CVD in terms of death and disability worldwide2. In 2011, heart disease accounted for 30.4% of all deaths in Singapore. Statistics published by the Singapore Heart Foundation show that heart disease claimed more than 5,480 Singaporean lives in 20113.
|Total No. Of Deaths||17,101||17,610||18,027|
|Total No. Of Deaths from Heart Disease||5,404||5,618||5,480|
CHD is typically caused by atherosclerosis1 of the coronary arteries. The coronary arteries are particularly vulnerable to atherosclerosis because they are small in diameter. If the coronary arteries are blocked for a prolonged length of time, parts of the heart muscle are deprived of oxygen and vital nutrients, which causes the affected area to die (myocardial infarction or heart attack).
In most cases, heart attack or severe chest pain (unstable angina) is also caused by a blood clot that reduced or blocked the flow of blood through an artery to the heart. Often, such blood clots are formed when atherosclerotic plaques rupture, causing blood platelets to clump together to form a blood clot. If a heart attack patient survives, he or she carries the risk of forming new blood clots in future, which may lead to another cardiovascular event. Oral antiplatelet agents, such as BRILINTATM work to lower this risk by preventing the platelets from clumping together.
- Atacand, Atacand Plus
1. World Health Report 2002. World Health Organization. http://who.int
2. Murray CJL, Lopez AD. Mortality by cause for the eight regions of the world: Global Burden of Disease Study. Lancet 1997; 349: 1269-76
3. Statistics from the Singapore Heart Foundation: http://www.myheart.org.sg/?page_id=51
4. "Antiplatelet agents". American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=4438 Last accessed September 30 2010.
Gastroesophageal reflux disease (GERD) is a chronic, relapsing acid-peptic disorder characterized by recurrent troublesome reflux symptoms1. The prevalence of GERD in Asia as reported from symptom-based studies ranges from <1.6% to 20%2.
1. Vakil N et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am. J. Gastroenterol 2006; 101:1900-20.
2. Goh KL. Gastroesophageal reflux disease in Asia: A historical perspective and present challenges. J Gastroenterol Hepatol 2011; 26 (Suppl. 1): 2-10.
Some 235 million people suffer from asthma. It is the most common chronic disease among children1. Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the world2.
1. World Health Organization. Chronic respiratory diseases. Available at http://www.who.int/respiratory/asthma/en. Accessed on Sept 9, 2013.
2. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. Updated 2013.
Osteoarthritis (OA) refers to a clinical syndrome of joint pain accompanied by varying degrees of functional limitation and reduced quality of life. It is the most common form of arthritis and one o the leading causes of pain and disability worldwide. Knees, hips and small hand joints are most commonly affected.
Rheumatoid arthritis (RA) is an inflammatory disease. It typically affects the small joints of the hands and the feet, and usually both sides equally and symmetrically, although any joint can be affected1. It is a systemic disease and so can affect the whole body, including the heart, lungs and eyes2.
1. The care and management of osteoarthritis in adults. NICE Clinical Guideline 59. Issued: February 2008.
2. The management of rheumatoid arthritis in adults. NICE Clinical Guideline 79. Issued: February 2009, modified August 2013.
Drug resistance is becoming more severe and many infections are no longer easily cured, leading to prolonged and expensive treatment and greater risk of death. Recognising the severity of this problem, the World Health Organization (WHO) selected “Combat Drug Resistance” as the theme for World Health Day 2011, calling for urgent action to safeguard drug treatments.
1. World Health Day 2011. Urgent action necessary to safeguard drug treatments. Available at http://www.who.int/mediacentre/news/releases/2011/whd_20110406/en/index.html. Accessed on Sept 9, 2013.
Humans are made up of cells. Within each cell are genes which direct and control all the cell's functions and determine how and when it divides and grows. Normal cells divide and grow at a controlled rate. How fast or slow a cell divides and grows, and what function it does, depends on the gene within that cell. Cancer begins as a change in the gene of a single normal cell in any part of the body. Once this change takes place, the set of instructions in the gene is changed and the cell no longer acts like it normally does. "Cancer" is actually due to the accumulation of many such errors.(i)
Lung cancer and breast cancer are the top most frequent cause of cancer deaths amongst men and women in Singapore respectively (ii)
(I) & (ii) National Cancer Centre Singapore. Retrieved from http://www.nccs.com.sg . Last accessed 4 October 2013.
Central Nervous System
It is estimated that around 450 million people worldwide have a mental health problem. In Singapore, neuropsychiatric disorders are estimated to contribute to 24.4% of the global burden of disease (WHO, 2008).
Central Nervous System range:
- Seroquel XR
Adverse event reporting
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AstraZeneca Singapore Pte Ltd
8 Wilkie Road #06-01 Wilkie Edge Singapore 228095
General phone line: +65 6579 6500
General fax line: +65 6238 7815