David Ruau is the Head of the Scientific Computing Solutions group in the B&I Advanced Analytics Centre at AstraZeneca.

After holding several academic positions at Stanford University, California, and the University of Cambridge, UK, David joined AstraZeneca in 2014.

Scientific Computing Solutions (SCS) is a data science group focusing on data mining and machine learning as well as providing innovative and scalable computational solutions for clinical trial data analysis and portfolio decisions. SCS support all quantitative aspects in the late-stage pipeline from Phase 3 clinical trial design to payer dossier data exploration.

David has authored more than 20 publications in Nature, Nature Methods, Science Translational Medicine, Cell, Cell Stem Cell, the Journal of Pain, PLoS. His research using Electronic Medical Records was featured in the New York Times, Time magazine, the Wall Street Journal, and on news networks such as the BBC, NPR, BBC and CNN. Additionally, David wrote two book chapters on data mining techniques used in functional genomics, one published by Springer and the latest is a textbook for bioinformatics for Cold Spring Harbor.

AstraZeneca has a fantastic culture open to new ideas and engaged with the scientific community to push the boundary of what is possible. I joined the Advanced Analytics Centre in GMD as this is the best place for me to deliver life changing solutions to patients.

David Ruau


Head of the Scientific Computing Solutions group in the Advanced Analytics Centre


Building an ENCODE-style data compendium on a shoestring. Nature Methods 2013


Integrative bioinformatics research


International Association for Study of Pain

  Featured publications

CBP and p300 facilitate leukemogenesis

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia. Giotopoulos G, Chan WI, Horton SJ, Ruau D, Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Göttgens B, Van Deursen JM, Cole PA, Huntly BJ. Oncogene 2015.doi:10.1038/onc.2015.92

Building an ENCODE-style data compendium

Building an ENCODE-style data compendium on a shoestring. Ruau D, Ng FS, Wilson NK, Hannah R, Diamanti E, Lombard P, Woodhouse S, Göttgens B. Nature Methods 2013; 10, 926. doi:10.1038/nmeth.2643

Sex differences in reported pain

Sex differences in reported pain across 11,000 patients captured in electronic medical records. Ruau D, Liu LY, Clark JD, Angst MS, Butte AJ. J Pain. 2012 13(3):228-34. doi: 10.1016/j.jpain.2011.11.002.


Distinguish paper award AMIA TBI 2011


Borcher medal, RWTH Aachen University


Research Award, Dept. of Anesthesia, Stanford University