My role as Head of External R&D and Strategic Alliances in Oncology is to maximize the value of our oncology portfolio by establishing collaborations and engaging with external experts. Sharing scientific knowledge with external partners and building alliances is crucial to drive innovation forward and accelerate the delivery of our next wave therapeutics.

In my current position, I am responsible for establishing and nurturing these external partnerships within oncology. One of our most exciting initiatives is the Partners of Choice Network, a global consortium between AstraZeneca and some of the top academic institutions and oncology medical centers. Our mission is to achieve the best outcomes for our potential therapeutics, which will ultimately improve the lives of patients.

I first joined AstraZeneca in 2017 as the Head of Immuno-Oncology External Development and Product Development Team Leader where I led oncology early and late programs, including the filing and approval of Lumoxiti to treat hairy cell leukemia. My career in oncology research started with my PhD in Tumor Immunology at the Roswell Park Cancer Institute, State University of New York. Since then, I have gained over 20 years of research and industry experience in oncology including biologics, immuno-oncology and antibody-drug conjugates.

Over the course of my career, I have led and managed cross-functional teams spanning all phases of research and development, from discovery and preclinical research up to early and late development, including life cycle management. It has been inspiring to work with so many dedicated and hardworking colleagues with the common goal of propelling novel cancer therapeutics towards the clinic.

 

I am excited that collaborating with external partners is providing us with new opportunities to fight cancer together. By sharing our knowledge, we can push the boundaries of innovation to deliver life-changing new medicines to patients.

Ezogelin Oflazoglu-Gruyters Vice-President, Head of External R&D and Strategic Alliances, Oncology R&D

CURRENT ROLE

Vice-President, Head of External R&D and Strategic Alliances, Oncology R&D

2018

Lead role in filing and approval of LUMOXITI™ for hairy cell leukemia

2017

Appointed as Head of Immuno-Oncology External Development and Product Development Team Leader at Medimmune

2013–2017

Development lead role in life cycle management of VIDAZA® and Ph3 development for CC-486 for acute myeloid leukemia at Celgene

 Featured publications

New realities of phase I clinical trials in the era of immuno-oncology: the durvalumab experience.

Abdullah S, Oflazoglu E, Soria JC, Dar MM. Ann Oncol. 2019 Dec 1;30(12):2004-2007.

Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker.

Oflazoglu E, Stone IJ, Gordon K, Wood CG, Repasky EA, Grewal IS, Law CL, Gerber HP. Clin Cancer Res. 2008 Oct 1;14(19):6171-80.

Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30.

Oflazoglu E, Stone IJ, Gordon KA, Grewal IS, van Rooijen N, Law CL, Gerber HP. 2007 Dec 15;110(13):4370-2.

Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities.

McEarchern JA, Oflazoglu E, Francisco L, McDonagh CF, Gordon KA, Stone I, Klussman K, Turcott E, van Rooijen N, Carter P, Grewal IS, Wahl AF, Law CL. 2007 Feb 1;109(3):1185-92.

Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates.

Kelley SK, Gelzleichter T, Xie D, Lee WP, Darbonne WC, Qureshi F, Kissler K, Oflazoglu E, Grewal IS. Br J Pharmacol. 2006 Aug;148(8):1116-23. Epub 2006 Jul 10. Erratum in: Br J Pharmacol. 2007 Jan;150(2):248.