Koustubh is a leader in human genetics and pharmacogenomics; more specifically, the application of genomics to drug development. As the VP, R&D, Translational Medicine, he leads a team that is responsible for employing genomics, bioinformatics and image analysis to translate the molecular heterogeneity that underlies disease into precision medicines.

Koustubh’s career began more than two decades ago when as a visiting fellow at the National Human Genome Research Institute, National Institutes of Health, he studied the genetics of melanoma. Following additional postdoctoral work on the genetics of complex diseases like hypertension and bipolar at the Stanford University School of Medicine, Koustubh moved to Bristol-Myers Squibb, where as Director, R&D, he spent nearly 10 years leading teams responsible for finding predictors of drug response. He later joined Genentech as an Associate Group Medical Director of Clinical Diagnostics. In 2010, Koustubh came to MedImmune and in his current role as VP, R&D, he oversees translational medicine research in the areas of cancer, respiratory, inflammation and autoimmune disease. He has published extensively on human genetics and pharmacogenomics; coauthored and edited a book on the application of genomics to drug development, and is an inventor on four issued patents.

LATEST PROJECT

Koustubh’s latest project is to understand the molecular heterogeneity underlying cancer in order to identify which patients are more likely to benefit from immuno-therapy, specifically, anti-PD-L1 and anti-CTLA4.

Ph.D. in Molecular Genetics from University of Massachusetts Medical School; Postdoctoral research at National Human Genome Research Institute, NIH and Stanford University School of Medicine

Featured publications

A switch in translation mediated by an antisense RNA

Ranade, K. and Poteete, A. R. (1993).  A switch in translation mediated by an antisense RNA.  Genes and Development 7: 1498-1507.

The superinfection exclusion (sieB) genes of bacteriophages P22 and lambda

Ranade, K. and Poteete, A. R. (1993).

Journal of Bacteriology 175: 4712-4718.

Mutations associated with familial melanoma impair p16ink4 function

Ranade, K., Hussussian, C., Sikorski, R., Varmus, H. E., Goldstein, A., Tucker, M., Serrano, M., Hannon, G., Beach, D. and Dracopoli, N. (1995).

Nature Genetics 10: 114-116.

Increased risk of pancreatic cancer in melanoma-prone kindreds with p16ink4 mutations

Goldstein, A., Fraser, M., Struewing, J., Hussussian, C. J., Ranade, K., Zametkin, D. P., Fontaine, L. S., Organic, S. M., Dracopoli, N. C., Clark, W. H., and Tucker, M. A. (1995).

New England Journal of Medicine 333: 970-974.

A locus for Fanconi Anemia on 16q determined by homozygosity mapping

Gschwend, M., Levran, O., Kruglyak, L., Ranade, K., Verlander, P. C., Shen, S., Faure, S., Weissenbach, J., Altay, C., Lander, E. S., Auerbach, A. D. and Botstein, D. (1996).

American Journal of Human Genetics  59: 377-384.

Optimized conditions for cloning PCR products into an XcmI T-vector

Schutte, B. C., Ranade, K., Pruessner, J. and Dracopoli, N. (1997).

Biotechniques 22: 40-44.

Full Genome Scan for linkage in fifty families segregating the Bipolar Affective Disease phenotype

Friddle, C., Koskela, R., Ranade, K., Hebert, J., Gschwend, M., Clark, C., McInnis, M., Simpson, S., McMahon, F., Stine, O., Meyers, D., Xu, J.,MacKinnon, D., Breschel, T., Jamison, K., Marr, T., Daly, M., Kruglyak, L., DePaulo, J. and Botstein, D. (2000).

American Journal of Human Genetics 66: 205-215.

Lack of evidence for an association between alpha-adducin and blood-pressure regulation in Asian populations

Ranade, K., Hsuing, A, Wu, K., Chang, M., Chen, Y., Hebert, J., Chen, I., Olshen, R., Curb, D., Dzau, V., Botstein, D., Cox, D. and Risch, N. (2000).

American Journal of Hypertension 13: 704-9. 

Evaluation of the association of the angiotensinogen gene with hypertension: The NHLBI Family Blood Pressure Program

Province, M., Boerwinkle, E., Chakravarti, A., Cooper, R., Fornage, M., Leppert, M., Risch, N., and Ranade, K. (2000).

Journal of Hypertension 18: 867-76.

Fluorescence Polarization in Homogeneous Nucleic Acids Analysis II: 5’ Nuclease Assay

Latif, S, Bauer-Sardina, I I, Ranade, K, Livak, KJ, Kwok, PY (2001).

Genome Research 11: 436-440.

High-throughput genotyping with single nucleotide polymorphisms

Ranade K, Chang M-S, Ting, C-T., Pei D, Hsiao C-F, Olivier M., Pesich R, Hebert J, Chen Y-I, Dzau VJ, Curb D, Olshen R, Risch N, Cox DR, Botstein D.  (2001).

Genome Research 11: 1262-1268.

Genetic variation in human urea transporter-2 is associated with variation in blood pressure

Ranade, K., Wu, K-D., Hwu, C-M., Ting, C-T., Pei, D., Pesich, R., Hebert, J. Chen, Y-D.I., Pratt, R., Olshen, R.A., Masaki, K., Risch, N., Cox, D.R., and Botstein, D. (2001).

Human Molecular Genetics 10: 2157-2164.

Genetic variation in aldosterone synthase predicts plasma glucose levels

Ranade K., Wu K., Risch N., Olivier M., Pei D, Hsiao C-F., Chuan L-M., Ho L-H., Jorgenson E., Pesich R., Chen Y-D.I., Dzau V., Lin A., Olshen R.A., Curb D., Cox D.R. and Botstein D. (2001).

Proceedings of the National Academy of Sciences, USA. 98: 13219-13224.

The Glycine allele of a Glycine/Arginine polymorphism in the β2 adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin

Ranade K, Shue W-H, Hung Y-I, Hsuing C-A, Chiang F-T, Pesich R, Hebert J, Olivier M, Chen Y-D, Pratt R, Olshen R, Curb D, Botstein D, Risch N and Cox D. R.  (2001).

American Journal of Hypertension, 14: 1196-1200.

Multi-centre Genetic Study of Hypertension

The Family Blood Pressure Program (FBPP).

Hypertension, 39: 3-9.

A polymorphism in the β1 adrenergic receptor is associated with resting heart rate

Ranade K., Jorgenson E., Sheu W-H.H., Pei D., Hsuing C.A., Chiang F-T., Chen Y.I., Pratt R., Olshen R., Curb D., Cox D.R., Botstein D. and Risch N.  (2002).

A polymorphism in the β1 adrenergic receptor is associated with resting heart rate.  American Journal of Human Genetics, 70: 935-942.

A Genome Scan for Hypertension Susceptibility Loci in Populations of Chinese and Japanese Origin

Ranade K, Hinds D, Hsuing C-A, Chuang L-M, Chang M-S, Chen Y-T, Pesich R, Hebert J, Chen Y-D. I, Dzau VJ, Olshen R, Curb D, Bostein D, Cox DR and Risch N (2003).

American Journal of Hypertension 16: 158-162.

A meta-analysis of genome-wide linkage scans: The National Heart Lung Blood Institute Family Blood Pressure Program (FBPP)

Province M. A., Kardia S. L., Ranade K., Rao D. C., Theil B. A., Cooper R. S., Risch N., Turner S. T., Cox D. R., Hunt S. C., Weder A. B. and Boerwinkle E (2003).

American Journal of Hypertension 16: 144-147.

Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24,18q22, 4q32, 2p12, and 13q12

McInnis MG, Lan TH, Willour VL, McMahon FJ, Simpson SG, Addington AM, MacKinnon DF, Potash JB, Mahoney AT, Chellis J, Huo Y, Swift-Scanlan T, Chen H, Koskela R, Colin Stine O, Jamison KR, Holmans P, Folstein SE, Ranade K, Friddle C, Botstein D, Marr T, Beaty TH, Zandi P, Raymond DePaulo J (2003).

Molecular Psychiatry 3: 288-98.

Tree-structured supervised learning and the genetics of hypertension

Huang J, Lin A, Narasimhan B, Quertermous T, Hsiung CA, Ho LT, Grove JS, Olivier M, Ranade K, Risch NJ, Olshen RA. (2004).

Proceedings of the  National Academy of  Sciences USA 101: 10529-10534.

Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg SNP in Paraoxonase 1 is associated with increased risk of stroke

Ranade K, Kirchgessner T., Iakoubova O., Devlin J., DelMonte T., Vishnupad P., Hui, L., Sabatine M., Sacks F., Braunwald E., White T., Shaw P., Dracopoli N (2005).

Stroke 36: 2346-2350.

Polymorphism in Kif6 gene and benefit from statins after acute coronary syndrome: results from the PROVE IT-TIMI 22 study

Iakoubova OA, Sabatine MS, Rowland CM, Tong CH, Catanese JJ, Ranade K, Simonsen KL, Kirchgessner TG, Cannon CP, Devlin JJ, Braunwald E. (2008).

J Am Coll Cardiol 51:449-55.

Association between ADAMTS1 matrix metalloproteinase Gene Variation, Coronary Heart Disease, and Benefit of Statin Therapy

Sabatine MS, Ploughman L, Simonsen KL, Iakoubova OA, Kirchgessner TG, Ranade K, Tsuchihashi Z, Zerba KE, Long DU, Tong CH, Packard CJ, Pfeffer MA, Devlin JJ, Shepherd J, Campos H, Sacks FM, Braunwald E. (2008).

Arterioscler. Throm Vasc Biol. 28: 562-567.

Genetic Analysis Implicates Resistin in HIV Lipodystrophy

Ranade K., Geese W., Noor M., Flint O., Tebas P., Mulligan K., Powderly W., Grinspoon S., Dube M.  (2008).

AIDS 13: 1561-8.

Genetic and Gene Expression Studies Implicate Renin and Endothelin in the Edema caused by Peroxisome-Proliferator Activated Receptor γ Agonists

Geese W., Achanzar W., Rubin C., Hariharan N., Cheng P., Tomlinson L., Ordway N., Dracopoli N., Delmonte T., Hui L., Krishnan B., Cosma G., Ranade K.  (2008).

Pharmacogenetics & Genomics 10: 903-10.

A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth

Genomic signatures characterize leukocyte infiltration in myositis muscles

Zhu W, Streicher K, Shen N, Higgs BW, Morehouse C, Greenlees L, Amato AA, Ranade K, Richman L, Fiorentino D, Jallal B, Greenberg SA, Yao Y.  (2012).

BMC Med Genomics. 5:53. doi: 10.1186/1755-8794-5-53.

MicroRNA-mediated regulation of innate immune response in rheumatic diseases

Luo X, Ranade K, Talker R, Jallal B, Shen N, Yao Y.  (2013).

Arthritis Research Therapies 15: 210.

The Plasma Cell Signature in Autoimmune Disease

Streicher K, Morehouse CA, Groves C, Rajan B, Pilataxi F, Lehmann K, Brohawn PZ, Higgs BW, McKeever K, Greenberg SA, Fiorentino D, Richman L, Jallal B, Herbst R, Yao Y, Ranade K. (2014).

Arthritis & Rheumatology, 66: 173-84.

Inhibition of myogenic MicroRNAs-1, -133, and -206 by Pro-Inflammatory Cytokines Links Inflammation and Muscle Degeneration in Myositis

Georgantas RW III, Streicher K (co-first authors), Greenberg SA, Greenlees L, Zhu W, Brohawn PZ,  Higgs BW, Czapiga M, Morehouse CA, Amato A, Richman L, Jallal B, Yao Y, and Ranade K. (2014).

Arthritis & Rheumatology, 66:1022-33.

Inhibition of microRNA-let-7a Increases the Productivity of Antibody-Producing CHO Cell Lines

Greenlees L, Georgantas RW III, Zhu J, Dong H, Clarke L, Stracener C, Roy G, Feng H, Yao Y, Bowen MA, Ranade K, and Streicher K. (2014).

Biotechnology and Bioengineering, in press.

MiR-206 Induces G1 Arrest by Inhibition of CDK4 and Cyclin D1 and is Down-Regulated in Melanoma

Georgantas RW III, Streicher K (co-first authors), Luo X, Greenlees L, Zhu W, Liu Z, Brohawn PZ, Morehouse CA Higgs BW, Richman L, Jallal B, Yao Y, and Ranade K. (2014).

Melanoma and Pigment Cell Research, 25:275-86.

Past, present, and future for biologic intervention in atopic dermatitis

Howell MD, Parker ML, Mustelin T, Ranade K. (2015).

Allergy 70(8):887-96

Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial

Reductions in eosinophil biomarkers by benralizumab in patients with asthma

A Sputum Proteomic Signature That Associates with Increased IL-1β Levels and Bacterial Exacerbations of COPD

Development of a new ARCHITECT automated periostin immunoassay

eanblanc NM, Hemken PM, Datwyler MJ, Brophy SE, Manetz TS, Lee R, Liang M, Chowdhury PS, Varkey R, Grant EP, Streicher K, Greenlees L, Ranade K, Davis GJ.  (2017).

464: 228-235.


Books:

Genomic Biomarkers in Pharmaceutical Development: Advancing Personalized Healthcare, Academic Press

Yao Y., Jallal B., Ranade K.  (2013).

Genotyping using the TaqMan assay in Current Protocols in Human Genetics, John Wiley & Sons, NY

Hui L., Delmonte T., Ranade, K. (2008).

We want re-define disease based on underlying molecular pathways, rather than on signs and symptoms, and translate this molecular understanding into precision medicines.

Koustubh Ranade, PhD VP, R&D Translational Medicine