Chronic kidney disease
What is chronic kidney disease?
Chronic kidney disease (CKD) is a debilitating condition in which kidney function is damaged over time.
The kidneys play an important role in filtering waste and fluids, contributing to the maintenance of blood glucose levels and controlling the production of red blood cells. CKD is a global public health issue, affecting an estimated 200 million people worldwide.
Because important commonalities have been found among CVD, CKD and diabetes, we are leading in this complex disease area by jointly addressing cardio-renal-metabolic risks.
Our aim is to address significant unmet needs in the management of CKD complications, and then to evaluate therapies that could modify or even halt CKD progression or provide cardiovascular benefit.
Novel approach to CKD research which aims to address both its complications and underlying causes
We are investing in ground-breaking science to develop new therapies that we believe will help prevent, treat, manage and modify CKD.
What we're working on
We are exploring renal science within the larger clinical context of cardio-renal-metabolic disease risk factors and comorbidities.
HARMONIZE-GL is a Phase III, multicentre, randomised, double-blind, placebo-controlled study designed to examine the efficacy of two doses of sodium zirconium cyclosilicate (ZS-9) in maintaining normokalaemia following two days of initial therapy. Patients are enrolled in more than 38 study locations to date, including Russia, Japan, Taiwan and South Korea.
Anaemia in CKD
AstraZeneca and FibroGen are collaborating on the development and commercialisation of roxadustat (FG-4592) for the treatment of anaemia in CKD in the US and China. Roxadustat is a oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors mimicking the body’s natural response to low oxygen levels to promote erythropoiesis in CKD patients.
Verinurad (RDEA3170) is a potent selective uric acid reabsorption inhibitor in Phase II development as a potential urate-lowering therapy. Hyperuricaemia has been linked to kidney and heart disease. We are investigating the effects of verinurad on kidney and/or heart function in patients with albuminuria, and the dosing of the first study participant occurred in Q2 2017.
We entered a collaboration with the University of Michigan to advance treatment of CKD and improve our understanding of the disease. The Renal Pre-Competitive Consortium (RPC2) will combine extensive clinical and molecular data to explore key pathways that drive the progression of CKD and identify potential new therapeutic targets for medicines.
DapaCare programme in renal
The DapaCare clinical programme will explore the CV and renal profile of dapagliflozin in people with and without type-2 diabetes.
The DapaCare programme currently involves nearly 30,000 patients across randomised clinical trials and is supported by a large real-world cohort study. Within the current programme, two studies are investigating renal endpoints:
Dapa-CKD: An international, event-driven, randomised, double-blind, parallel group, placebo-controlled study evaluating the effect of dapagliflozin in addition to the standard of care to prevent the progression of CKD or CV/renal death.
DELIGHT: An exploratory Phase II/III, randomised, double-blind, placebo-controlled study to evaluate the efficacy, safety and pharmacodynamics of dapagliflozin and dapagliflozin in combination with saxagliptin in patients with type-2 diabetes, CKD stage 3 and albuminuria.
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4. U.S. National Institutes of Health. “A Study to Investigate the Safety and Efficacy of ZS in Patients With Hyperkalemia (HARMONIZE GL).” NCT02875834. 2017. Accessed 15 August 2017. https://clinicaltrials.gov/ct2/show/NCT02875834?term=harmonize+GL&rank=1.
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6. ClinicalTrials.gov. Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure (Dapa-HF). Available at https://clinicaltrials.gov/ct2/show/NCT03036124.
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Veeva ID: Z4-9559
Date of next review: March 2020