Eosinophil-Driven Diseases (EDDs)

Our ambition to address unmet needs for people with EDDs

Our commitment to eosinophil-driven diseases

Building on a 50-year heritage in respiratory care and following the science of common pathways and underlying disease drivers from respiratory disease into immunology-driven disease areas, we’re continuing to better understand the important role of eosinophils as key effector cells in a range of potentially devasting inflammatory diseases, also known as eosinophil-driven diseases (EDDs).

EDDs are inflammatory illnesses in which elevated eosinophils are a direct cause or are thought to play a critical role.1 Some EDDs have limited or no approved treatment options, creating a significant unmet need for innovative medicines. We know now that a process called eosinophilic immune dysfunction may be responsible for the eosinophil recruitment and activation that is driving these diseases. Backed by a growing body of evidence, we’re committed to advancing the understanding of the role of eosinophils in inflammatory diseases across Respiratory & Immunology, with the aim to improve diagnosis, patient referrals and timely, appropriate treatment.

 



Patient Portraits



Types of eosinophil-driven diseases

We are currently investigating potential medicines to treat inflammatory, EDDs where unmet medical need remains significant and, in some cases, where we see an increasing prevalence.











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At AstraZeneca, we’re driven by innovation and our commitment to make a real-life difference in patients’ lives. Join us and help deliver life-changing medicines. Be among our employees who continue to make us an innovation-driven company that stands firmly among the world’s leaders in biopharmaceuticals. 
 




References

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2. Ramirez GA, Yacoub MR, Ripa M, et al. Eosinophils from physiology to disease: a comprehensive review. Biomed Res Int. 2018; 9095275.

3. Silverberg JI. Comorbidities and the impact of atopic dermatitis. Ann Allergy Asthma Immunol. 2019;123 (2): 144-151

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8. American Academy of Allergy Asthma & Immunology. Hives (urticaria) and Angioedema overview Available at: https://www.aaaai.org/conditions-and-treatments/library/allergy-library/hives-angioedema. [Last accessed: December 2020].

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11. Coumou H, Bel EH. Improving the diagnosis of eosinophilic asthma. Expert Rev Respir Med. 2016;10(10): 1093-1103.

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13. American Partnership for Eosinophilic Disorders. EoE. Available at: https://apfed.org/about-ead/egids/eoe. [Last accessed: December 2020].

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18. Lucendo AJ, López-Sánchez P. Targeted Therapies for Eosinophilic Gastrointestinal Disorders. BioDrugs 2020; 34: 477–493 

19. American Partnership for Eosinophilic Disorders. Eosinophilic Granulomatosis with Polyangiitis (EGPA). Available at: https: apfed.org/about-ead/eosinophilic-granulomatosis-with-polyangiitis/. [Last accessed: December 2020].

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28. Abdalla S, Alreefy H, Hopkins C. Prevalence of sinonasal outcome test (SNOT-22) symptoms in patients undergoing surgery for chronic rhinosinusitis in the England and Wales National prospective audit. Clin Otolaryngol. 2012; 37 (4): 276-282.


Veeva ID: Z4-29652

Date of Prep: December 2020