Eosinophilic Immune Dysfunction

Our ambition to address unmet needs for people living with inflammatory diseases driven by eosinophilic immune dysfunction


Our commitment to uncovering eosinophilic immune dysfunction

Building on a 50-year heritage in respiratory care and following the science of common pathways and underlying disease drivers from respiratory disease into immunology-driven disease areas, we’re continuing to better understand the important role of eosinophils as key effector cells in a range of potentially devasting inflammatory diseases.

Some of these eosinophilic diseases have limited or no approved treatment options, creating a significant unmet need for innovative medicines. We know now that a process called eosinophilic immune dysfunction may be responsible for the eosinophil recruitment and activation that is driving these diseases. Backed by a growing body of evidence, we’re committed to advancing the understanding of the role of eosinophils in inflammatory diseases across Respiratory & Immunology, with the aim to improve diagnosis, patient referrals and timely, appropriate treatment.
 



When eosinophils are present in inflammatory disease, eosinophilic immune dysfunction may be the cause. Knowledge of eosinophilic immune dysfunction will help raise awareness that seemingly disparate diseases actually have a common cause – eosinophilic inflammation – that ties them all together

Mark White Global Franchise Head

Patient Portraits


Disease States

We are currently exploring potential medicines across a broad range of diseases that may be driven by eosinophilic immune dysfunction and where unmet medical need remains significant and, in some cases, where we see an increasing prevalence.











Join us


At AstraZeneca, we’re driven by innovation and our commitment to make a real-life difference in patients’ lives. Join us and help deliver life-changing medicines. Be among our employees who continue to make us an innovation-driven company that stands firmly among the world’s leaders in biopharmaceuticals. 
 




References

1. American Partnership for Eosinophilic Disorders. What is an eosinophil associated disease? Available at: https://apfed.org/about-ead/what-is-an-eosinophil-associated-disease/. [Last accessed: December 2020].

2. Ramirez GA, Yacoub MR, Ripa M, et al. Eosinophils from physiology to disease: a comprehensive review. Biomed Res Int. 2018; 9095275.

3. Silverberg JI. Comorbidities and the impact of atopic dermatitis. Ann Allergy Asthma Immunol. 2019;123 (2): 144-151

4. National Organisation for Rare Disorders. Bullous Pemphigoid. Available at: https://rarediseases.org/rare-diseases/bullous-pemphigoid. [Last accessed: December 2020].

5. GOLD. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2020. [Online]. Available at: https://goldcopd.org/wp-content/uploads/2019/12/GOLD-2020-FINAL-ver1.2-03Dec19_WMV.pdf [Last accessed: December 2020].

6. Adeloye D, Chua S, Lee C, et al. Global Health Epidemiology Reference Group (GHERG). Global and regional estimates of COPD prevalence: Systematic review and meta-analysis. J Glob Health. 2015; 5 (2): 020415.

7. Quaderi SA, Hurst JR. The unmet global burden of COPD. Glob Health Epidemiol Genom. 2018; 3: e4.

8. American Academy of Allergy Asthma & Immunology. Hives (urticaria) and Angioedema overview Available at: https://www.aaaai.org/conditions-and-treatments/library/allergy-library/hives-angioedema. [Last accessed: December 2020].

9. Maurer M, Abuzakouk M, Bérard F, et al. The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSU. Allergy. 2017; 72: 2005–2016.

10. Wenzel SE. Severe asthma in adults. Am J Respir Crit Care Med. 2005; 172: 149-160.

11. Coumou H, Bel EH. Improving the diagnosis of eosinophilic asthma. Expert Rev Respir Med. 2016;10(10): 1093-1103.

12. Trivedi SG, Lloyd CM. Eosinophils in the pathogenesis of allergic airways disease. Cell Mol Life Sci. 2007; 64 (10): 1269-1289.

13. American Partnership for Eosinophilic Disorders. EoE. Available at: https://apfed.org/about-ead/egids/eoe. [Last accessed: December 2020].

14. Naramore S, Gupta SK. Non-esophageal eosinophilic gastrointestinal disorders: clinical care and future directions. J Pediatr Gastroenterol Nutr. 2018; 67: 318–21.

15. Zhang M, Li Y. Eosinophilic gastroenteritis: a state-of-the-art review: Eosinophilic gastroenteritis. J Gastroenterol Hepatol. 2017; 32: 64–72.

16. Walker MM, Potter M, Talley NJ. Eosinophilic gastroenteritis and other eosinophilic gut diseases distal to the oesophagus. Lancet Gastroenterol Hepatol. 2018; 3 (4): 271-280.

17. Bedell A, Taft T, Craven MR, et al. Impact on Health-Related Quality of Life in Adults with Eosinophilic Gastritis and Gastroenteritis: A Qualitative Assessment. Dig Dis Sci. 2018; 63 (5): 1148-1157.

18. Lucendo AJ, López-Sánchez P. Targeted Therapies for Eosinophilic Gastrointestinal Disorders. BioDrugs 2020; 34: 477–493 

19. American Partnership for Eosinophilic Disorders. Eosinophilic Granulomatosis with Polyangiitis (EGPA). Available at: https: apfed.org/about-ead/eosinophilic-granulomatosis-with-polyangiitis/. [Last accessed: December 2020].

20. Baldini C, Talarico R, Della Rossa A, Bombardieri S. Clinical Manifestations and Treatment of Churg-Strauss Syndrome. Rheum Dis Clin N Am. 2010; 36: 527-543.

21. American Partnership for Eosinophilic Disorders. Hypereosinophilic Syndromes. Available at: https://apfed.org/about-ead/hypereosinophilic-syndrome/. [Last accessed: December 2020].

22. American Partnership for Eosinophilic Disorders. APFED Hypereosinophilic Syndromes Brochure. December 2017. Available at: http://apfed.org/wp-content/uploads/2017/12/APFED_HES_bro_final.pdf. [Last accessed: December 2020].

23. Bachert C, Akdis CA. Phenotypes and Emerging Endotypes of Chronic Rhinosinusitis. J Allergy Clin Immunol Pract. 2016; 4 (4): 621-628.

24. Newton JR, Ah-See KW. A review of nasal polyposis. Ther Clin Risk Manag. 2008; 4 (2): 507-512.

25. Fujieda S Imoto Y, Kato Y, et al. Eosinophilic chronic rhinosinusitis. Allergology Int. 2019; 68 (4): 403-412.

26. Hopkins C. Chronic Rhinosinusitis with Nasal Polyps. N Engl J Med. 2019; 381 (1): 55-63.

27. Stevens WW, Schleimer RP, Kern RC. Chronic Rhinosinusitis with Nasal Polyps. J Allergy Clin Immunol Pract. 2016; 4 (4): 565-572.

28. Abdalla S, Alreefy H, Hopkins C. Prevalence of sinonasal outcome test (SNOT-22) symptoms in patients undergoing surgery for chronic rhinosinusitis in the England and Wales National prospective audit. Clin Otolaryngol. 2012; 37 (4): 276-282.


Veeva ID: Z4-32697

Date of Prep: April 2021