Eosinophilic Immune Dysfunction

Our ambition to address unmet needs for people living with inflammatory diseases driven by eosinophilic immune dysfunction

Our commitment to uncovering eosinophilic immune dysfunction

Building on a 50-year heritage in respiratory care and following the science of common pathways and underlying disease drivers from respiratory disease into immunology-driven disease areas, we’re continuing to better understand the important role of eosinophils as key effector cells in a range of potentially devasting inflammatory diseases.

Some of these eosinophilic diseases have limited or no approved treatment options, creating a significant unmet need for innovative medicines. We know now that a process called eosinophilic immune dysfunction may be responsible for the eosinophil recruitment and activation that is driving these diseases. Backed by a growing body of evidence, we’re committed to advancing the understanding of the role of eosinophils in inflammatory diseases across Respiratory & Immunology, with the aim to improve diagnosis, patient referrals and timely, appropriate treatment.

When eosinophils are present in inflammatory disease, eosinophilic immune dysfunction may be the cause. Knowledge of eosinophilic immune dysfunction will help raise awareness that seemingly disparate diseases actually have a common cause – eosinophilic inflammation – that ties them all together

Mark White Global Franchise Head

Patient Portraits

Disease States

We are currently exploring potential medicines across a broad range of diseases that may be driven by eosinophilic immune dysfunction and where unmet medical need remains significant and, in some cases, where we see an increasing prevalence.

Join us

At AstraZeneca, we’re driven by innovation and our commitment to make a real-life difference in patients’ lives. Join us and help deliver life-changing medicines. Be among our employees who continue to make us an innovation-driven company that stands firmly among the world’s leaders in biopharmaceuticals. 


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Veeva ID: Z4-32697

Date of Prep: April 2021