Neuroscience
Advancing patient care in neurodegenerative diseases with unmet medical needs
AstraZeneca is committed to discovering and developing compounds that improve patient care in neuroscience.
With a rich heritage and a research and development focus on specific aspects of neurodegenerative diseases, analgesia and psychiatry, AstraZeneca continues to push the boundaries of science in neuroscience in collaboration with other innovative partners across industry and academia. A significant unmet medical need remains in the areas of cognitive disorders, chronic pain and other central nervous system disorders.
Our focus on unmet medical needs
More than 450 million people worldwide are affected by mental, neurological or behavioural problems, and the number is steadily rising.
-
Alzheimer's disease (AD)
AD is a fatal illness that causes progressive decline in memory and other aspects of cognition.
-
Opioid-induced constipation (OIC)
OIC is a condition caused by prescription opioid pain medicines. Millions of patients are treated with opioids each year.
What we're working on
We are committed to developing novel therapies that advance the science of neurodegenerative diseases and have the potential to provide a positive impact on patients around the world.
MEDI1814
MEDI1814 is a monoclonal antibody currently in Phase I development as a potential disease-modifying treatment for Alzheimer’s disease (AD). MEDI1814 is the first antibody to selectively target amyloid-beta 42, a form of amyloid which is particularly associated with AD. The build-up of plaque in the brain containing the peptide amyloid-beta is one of the key characteristics of AD. Early trials have shown that MEDI1814 can reduce levels of this more toxic form of amyloid-beta in Alzheimer’s disease patients.
AstraZeneca and Lily are co-developing MEDI1814 as part of the BACE alliance.
Image: Artistic rendering of BACE enzyme.
Collaboration stories
Partnering with influential organisations to extend the reach of our science to more patients and healthcare providers
AstraZeneca and Daiichi Sankyo Jointly Commercialise MOVANTIK in the US
Opioid-induced constipation is a condition caused by prescription opioid pain medicines. The AstraZeneca and Daiichi Sankyo partnership expands our efforts in the US in order to get MOVANTIK to the large number of patients suffering with opioid-induced constipation.
Opportunities for collaboration
Our approach in Neuroscience looks to maximise revenue through externalisation and on-market products; advance the novel product pipeline with partnerships where appropriate; and preserve a company stake in the most promising assets.
Our medicines
We cannot provide detailed information about our prescription medicines on this website, in compliance with regulations. Our medicines are approved in individual countries for specific uses and the information we provide for patients is governed by local regulations. In some cases, health care professionals and patients can visit local AstraZeneca websites to find out more about our medicines. Please note that in some countries we are not allowed to provide very much, or sometimes any, information on our prescription medicines so you should seek alternative trustworthy sources. Always ask a healthcare professional for advice about medicines.
Diprivan
propofol
EMLA
EMLA
Movantik/Moventig
naloxegol
Naropin
ropivacaine
Seroquel IR
quetiapine fumarate
Seroquel XR
quetiapine fumarate
Xylocaine
lidocaine
Zomig, Zomig Rapimelt, Zomig Nasal Spray, AscoTop, Zomigon
zolmitriptan
Resources
Sharing clinical trials information
We publish information about the registration and results of all new and ongoing clinical trials for all products in all phases on our dedicated website.
Information about our medicines
Our medicines are approved in individual countries for specific uses. Visit your local AstraZeneca site to find out more
Latest news
Join AstraZeneca
and help us deliver life-changing medicines
Be among our employees who continue to make us an innovation-driven company that stands firmly among the world’s leaders in biopharmaceuticals.
Veeva ID: Z4-17491
Date of next review: 07/06/2021