Lauren Drowley is an Associate Principal Scientist in the Cardiac Regeneration team at AstraZeneca in Gothenburg, Sweden.
Lauren received her PhD on stem cell transplantation for myocardial infarct repair from University of Pittsburgh. This was followed by a postdoctoral position at AstraZeneca in the UK, where she developed high content imaging assays with stem/progenitor cell populations for diabetes/obesity indications and examined the role of miRNA in cell differentiation.
In her current role as a stem cell specialist, she is characterising primary adult and iPS-derived stem cell populations, developing and implementing phenotypic proliferation and differentiation assays for cardiac repair, and assessing potential drug targets. In addition, she serves as biology lead on several drug projects and manages collaborations with academic partners.
Searching for a cure for heart failure
Developing stem cell-based phenotypic assays
Characterizing cardiac progenitor cell populations
SLAS Young Scientist 2011
Human Myogenic Endothelial Cells Exhibit Chondrogenic and Osteogenic Potentials
Human Myogenic Endothelial Cells Exhibit Chondrogenic and Osteogenic Potentials at the Clonal Level. Bo Zheng, Guangheng Li, William C.W. Chen, Bridget M. Deasy,Jonathan B. Pollett, Bin Sun, Lauren Drowley, Burhan Gharaibeh,Arvydas Usas, Bruno Pe ́ault, Johnny Huard. Journal of Orthopaedic Research 2013; 31(7): 1089-95. DOI: 10.1002/jor.22335
Loading stem cells to improve transplantation outcome
Mechanical loading of stem cells for improvement of transplantation outcome in a model of acute myocardial infarction: the role of loading history. Theresa R Cassino, Lauren Drowley, Masaho Okada, Sarah A Beckman, Bradley Keller, Kimimasa Tobita, Philip R Leduc, Johnny Huard. Tissue Engineering Part A. 2012; 18(11-12):1101-8. DOI: 10.1089/ten.TEA.2011.0285
Skeletal muscle cells improve ischemic heart function
Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of ischemic hearts. Masaho Okada, Thomas R Payne, Lauren Drowley, Ron J Jankowski, Nobuo Momoi, Sarah Beckman, William C W Chen, Bradley B Keller, Kimimasa Tobita, Johnny Huard. Molecular Therapy 2011; 20(1):138-45. DOI: 10.1038/mt.2011.229
Young Scientist Poster Award
Society for Laboratory Automation and Screening, 2011
NIH predoctoral training grant
Cellular Approaches to Tissue Engineering and Regeneration
I am really excited about the work in cardiac regeneration – the focus on using cells derived from patients and the use of phenotypic screening will allow us to identify both novel and biologically relevant compounds that could really help patients in the future.
Be among our employees who continue to make us an innovation-driven company that stands firmly among the world’s leaders in biopharmaceuticals.