Nicolas J. Guzman, M.D. has been the Director of Nephrology Clinical Research at AstraZeneca since 2014. He previously served as Associate Professor of Medicine in the division of Renal Disease and Hypertension at the George Washington University Medical Center.

His areas of clinical expertise include chronic kidney disease, cardiovascular disease risk, acute renal failure and studying the relationship between renal disease and cardiovascular complications. Other areas of focus include arterial hypertension, specifically hypertension in chronic kidney disease, clinical pharmacology and toxicology, and medical education and technology. Dr. Guzman, an established research lead, has been invited to a variety of lectures and conferences to speak about his work. He has served on many scientific review, advisory and editorial review boards as a trusted expert. Dr. Guzman’s vast experience in the cardio-renal disease space continues to make him a valuable asset to AstraZeneca and to the chronic kidney disease franchise.


With chronic kidney disease affecting more than 200 million people worldwide, I am proud that AstraZeneca is taking the lead and is fully committed to building a portfolio that will establish us as a scientific leader in the cardio-renal space.

Nicolas Jose Guzman, M.D. Director, Nephrology Clinical Research; CVMD US Group Director

LATEST PROJECT

Director, Nephrology Clinical Research AstraZeneca GMD, CVMD

ASSOCIATE PROFESSOR

Associate Professor of medicine at the Division of Renal Diseases and Hypertension, The George Washington University (2000-present)

DIRECTOR OF ACUTE DIALYSIS AND RENAL SUPPORT SERVICES

Director of Acute Dialysis and Renal Support Services, Division of Renal Diseases and Hypertension, The George Washington University (2013-2014)

DIRECTOR OF OUTPATIENT CLINICS

Director of Outpatient Clinics, Division of Renal Diseases and Hypertension, The George Washington University (2010-2014)

DIRECTOR OF DIABETES AND RENAL DISEASE CLINIC

Director of Diabetes and Renal Disease Clinic, Division of Renal Diseases and Hypertension, The George Washington University (2009-2012)

DIRECTOR, MOLECULAR SIGNALING LABORATORY

Director, Molecular Signaling Laboratory, Division of Nephrology and Hypertension, Georgetown University Medical Center (1995-1999)


Featured publications

Chronic Kidney Disease Outcomes

Gupta J, Mitra N, Kanetsky PA, Devaney J, Wing MR, Reilly M, Shah VO, Balakrishnan VS, Guzman NJ, Girndt M, Periera BG, Feldman HI, Kusek JW, Joffe MM, Raj DS; CRIC Study Investigators: Chronic Renal Insufficiency Cohort (CRIC) Study: Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC. Clin J Am Soc Nephrol. 2012 Dec; 7(12):1938-46

Wing MR, Yang W, Teal V, Navaneethan S, Tao K, Ojo A, Guzman NJ, Reilly M, Wolman M, Rosas SE, Cuevas M, Fischer M, Lustigova E, Master SR, Xie D, Appleby D, Joffe M, Kusek J, Feldman HI, Raj DS, Chronic Renal Insufficiency Cohort (CRIC) Study: Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: finding from the chronic renal insufficiency cohort study. Obesity (Silver Spring). 2014 May; 22(5):1359-66

Wing MR, Devaney JM, Joffe MM, Xie D, Feldman HI, Dominic EA, Guzman NJ, Ramezani A, Susztak K, Herman JG, Cope L Harmon B, Kwabi-AddoB, Go AS, He J, Lash JP, Kusek JW, Raj DS, Chronic Renal Insufficiency Cohort (CRIC) Study: DNA Methylation Profile Associated with Rapid Decline in Kidney Function: Findings from the CRIC Study. Nephrol Dial Transplant. 2014 Apr; 29(4):864-72

Hypertension and Kidney Disease of Diabetes Mellitus. A Review

Guzman NJ: Hypertension and Kidney Disease of Diabetes Mellitus. A Review. J. Florida M. A. 1991; 78(11):751-753.

Acute Renal Failure

Guzman NJ and Peterson JC: Acute Renal Failure. In: Tisher CC and Wilcox CS, eds. Nephrology. 3rd ed. Baltimore: Williams & Wilkins, 1995; 69-82.

 

Use of Drugs in Renal Failure

Guzman NJ: Use of Drugs in Renal Failure. In: Tisher CC and Wilcox CS, eds. Nephrology. 3rd ed. Baltimore: Williams & Wilkins, 1995; 277-290.

Screening for Primary Hyperaldosteronism in CKD Patients with Resistant Hypertension: An Evaluation of Practice Patterns (Abstract Presentation)

Screening for Primary Hyperaldosteronism in CKD Patients with Resistant Hypertension: An Evaluation of Practice Patterns - Antonio Ligon MD, Samir Patel MD and Nicolas Guzman MD - Mid-Atlantic Fellows Forum 2010, Baltimore, MD.

Drug Overdose and Poisoning

Guzman NJ and Friedman PA : Drug Overdose and Poisoning. In: Parrillo JE, ed. Current Therapy in Critical Care Medicine, Philadelphia, Pennsylvania : B.C. Decker, 1987; 318-323.


Awards and honors

American Society of Hypertension

Specialist in Clinical Hypertension Certificate

American Board of Internal Medicine

Subspecialty of Nephrology, Diplomate

Diplomate

American Board of Internal Medicine