Join us
If you believe in the power of what science can do, join us in our endeavour to push the boundaries of science to deliver life-changing medicines.
Through our collaboration with Silence Therapeutics, we aim to develop novel, targeted treatments to address significant unmet need for the treatment of Cardiovascular, Renal, Metabolic and Respiratory diseases.
Harnessing Silence’s established siRNA platform, the collaboration will identify and progress liver-based targets, as well as develop new delivery approaches for targeting other tissues such as the heart, lungs and kidneys. Targeted delivery to these other tissues represents a new opportunity to treat Cardiovascular, Renal, Metabolic and Respiratory diseases.
The collaboration with Silence adds an exciting modality, siRNA, to our toolbox to help us develop novel therapeutics and address unmet medical needs.
1. Dana H, Chalbatani GM, Mahmoodzadeh H, et al. Molecular Mechanisms and Biological Functions of siRNA. Int J Biomed Sci. 2017;13(2):48-57.
2. Humphreys SC, Thayer MB, Campbell J, et al. Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development. J Med Chem. 2020;63(12):6407-6422.
3. Setten RL, Rossi JJ, Han SP. The current state and future directions of RNAi-based therapeutics [published correction appears in Nat Rev Drug Discov. 2019 Mar 18;:] [published correction appears in Nat Rev Drug Discov. 2019 Apr 24;:]. Nat Rev Drug Discov. 2019;18(6):421-446.
If you believe in the power of what science can do, join us in our endeavour to push the boundaries of science to deliver life-changing medicines.
We know that however innovative our science, however effective our medicines and delivery, to achieve all we want to achieve, we cannot do it alone.