Menelas Pangalos

Robbins MJ, Calver AR, Fillipov AK, Couve A, Moss SJ and Pangalos MN. The GABAB2 subunit is essential for G protein coupling of the GABAB receptor heterodimer. J. Neuroscience (2001) 21: 8043-8052.
http://www.jneurosci.org/content/21/20/8043.full.pdf

Couve A, Thomas P, Calver A, Hirst WD, Pangalos MN, Walsh FW, Smart T and Moss SJ. A role for cAMP dependent protein kinase phosphorylation in facilitating GABAB receptor effector coupling Nature Neuroscience (2002) 5: 1-10.
http://www.nature.com/neuro/journal/v5/n5/full/nn833.html

Kuramoto N, Wilkins M, Fairfax B, Revilla-Sanchez R, Tamaki K, Couve A, Calver AR, Horvath Z, Freeman K, Carling D, Huang L, Cooper E, Gonlazes C, Cooper E, Smart TG, Pangalos MN, Moss SJ. Phospho-dependent functional modulation of GABA_B receptors by the metabolic sensor AMP-dependent protein kinase. Neuron. (2007) 53:233-247.
http://www.cell.com/neuron/abstract/S0896-6273(06)01020-8

Terunuma M, Vargas KJ, Wilkins ME, Ramirez OA, Pangalos MN, Smart TG, Moss SJ and Couve A. Prolonged activation of NMDA receptors induces dephosphorylation and degradation of GABAB receptors. PNAS (2010) 107(31):13918-23.
http://www.pnas.org/content/107/31/13918.full

Terunuma M, Revilla-Sanchez R, Quadros IM, Deng Q, Deeb TZ, Lumb M, Sicinski P, Haydon PG, Pangalos MN and Moss SJ. Postsynaptic GABAB Receptor Activity Regulates Excitatory Neuronal Architecture and Spatial Memory.  J Neurosci (2014) 34:804-816.
http://www.jneurosci.org/content/34/3/804.full.pdf

Jacobsen JS, Wu C-C, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH and  Bloom FE. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer’s disease. PNAS (2006) 103: 5161-5166.
http://www.pnas.org/content/103/13/516

Jacobsen SJ, Comery TA, Marton RL, Elkodah H, Crandall DL, Oganesian A, Aschmies S, Kirksey Y, Gonzalez C, Xu J, Zaleska MM, Das I, Arias RL, Bard J, Riddell D, Gardell SJ, Abou-Gharbia M, Robichaud A, Magolda R, Vlasuk GP, Bjornsson T, Reinhart PH, Pangalos MN. Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. PNAS (2008) 105: 8754-8759.
http://www.pnas.org/content/105/25/8754.ful

Riddell DR, Kirksey Y, Hu Y, Warwick HK, Li Zhutting, Zhou H, Jacobsen JS, Pangalos MN and Reinhart PH and. Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci. (2008) 28(45):11445-11453.
http://www.jneurosci.org/content/28/45/11445.full.pdf

Basi G, Pangalos MN and Schenk D. Amyloid based treatments for Alzheimer’s disease. In The Biology of Alzheimer’s Disease, edited by Holtzman D, Mandelkow E and Selkoe D (2012) 423-454.

Holtzman DM, Nikolich K, Pangalos MN, Broich K, Ip NY, Koo EH, Koroshetz WJ, Masliah E, Mucke L, Nicotera P, Schnaars M, Spillantini MG. Neurodegenerative Diseases; What Is to Be Done? “Translational Neuroscience: Toward New Therapies” Strüngmann Forum Reports Series ed. J. Lupp. Cambridge, MIT Press (2015).

Cooke D, Brown D, Alexander R, March R, Morgan P, Satterthwaite G and Pangalos MN. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework. Nature Drug Discovery (2014) 13, 419–431.
http://www.nature.com/nrd/journal/v13/n6/full/nrd4309.html

Frail D, Wegner C, Sanganee H, Brady M, Escott J, Pangalos MN, Holt A and Watkins C. Pioneering Government-Sponsored, Collaborative Drug Repositioning Initiatives: Progress and Learning. Nature Reviews Drug Discovery (2015) in press.