Cardiovascular and Metabolic diseases

Following the science to help people maintain and improve cardiovascular and metabolic health

An enduring, bold ambition to break through conventional thinking in cardiovascular and metabolic health

AstraZeneca has a patient-centric approach to disease treatment, so we are tackling multiple risk factors by uniting our cardiovascular (CV), metabolic and chronic kidney disease (CKD) disease areas into one integrated approach – cardiovascular and metabolic disease (CVMD).

This approach means we look at the CVMD patient as a whole, rather than by disease area, because we know that cardiovascular disease (CVD) is a well-known consequence of diabetes and CKD. Each of our focus areas seek to further reduce cardiovascular morbidity and mortality, and organ damage by addressing multiple CV risk factors.

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AstraZeneca has been driving CV innovation for more than 100 years. As we aim to break through conventional thinking by following what the science is telling us, we will:

  • continue to build our CV and diabetes portfolio to help a broader range of patients
  • focus on investigating the impact of treatment options on reducing CV events and death in a broad range of high-risk patients, beyond acute coronary syndromes (ACS)
  • shift the treatment paradigm of Type 2 diabetes to early combination therapy and accelerate achievement of treatment goals
  • develop new therapies for anaemia in people with CKD.

Our enduring goal is to push the boundaries of science to deliver life-changing medicines to the people who need them, and contribute to improved health for millions more people around the world.

Our focus on unmet needs

  • CVD

    Cardiovascular disease is responsible for 30% of all deaths globally, one in three deaths in the US and more than half of all deaths across Europe.


  • ACS

    Acute coronary syndromes, which include heart attack and unstable angina, are responsible for almost half of all deaths worldwide related to cardiovascular disease.


  • Diabetes

    Diabetes is a growing disease and an enormous global burden that is currently projected to affect more than 592 million people by the year 2035.


  • CKD

    Chronic kidney disease is a complex, debilitating condition that affects more than 70 million people worldwide and more than 20 million adults in the US.


What we're working on

As part of our commitment to CVMD, here you can find highlights of our key areas of focus.

Our pipeline

Our current pipeline forms a robust portfolio of investigational therapies in varied stages of clinical development.

Phase 3/Reg.* refers to assets that are in Phase 3 or that have been submitted for regulatory approval, and may include assets that are now launched in one or more major markets.

Cardiovascular and Metabolic diseases (as at 10 November 2016)

Phase 1

Phase 1

  • AZD4076 non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NASH)
  • AZD4831 HFpEF
  • AZD5718 CAD
  • MEDI8111 trauma/bleeding

Phase 2

Phase 2

  • MEDI0382 diabetes/obesity
  • MEDI4166 diabetes/cardiovascular
  • MEDI6012 ACS

Phase 3

Phase 3

  • Brilinta/Brilique arterial thrombosis
  • Epanova severe hypertriglyceridaemia
  • Farxiga/Forxiga type-2 diabetes
  • ZS-9 (sodium-zirconium cyclosilicate) hyperkalaemia
  • roxadustat OLYMPUS ROCKIES anaemia in CKD/ESRD

LCM Projects

LCM Projects

  • Brilinta/Brilique PEGASUS- TIMI 54 outcomes study in patients with prior myocardial infarction
  • Brilinta/Brilique HESTIA prevention of vaso-occlusive crises in paediatric patients with sickle cell disease
  • Brilinta/Brilique THEMIS outcomes study in patients with type-2 diabetes and CAD, but without a previous history of MI or stroke
  • Bydureon EXSCEL type-2 diabetes outcomes study
  • Bydureon weekly suspension type-2 diabetes
  • Epanova STRENGTH outcomes study in statin-treated patients at high CV risk, with persistent hypertriglyceridemia plus low HDL-cholesterol
  • Farxiga/Forxiga type-1 diabetes
  • Farxiga/Forxiga DECLARE- TIMI 58 type-2 diabetes outcomes study
  • Kombiglyze XR/Komboglyze type-2 diabetes
  • Onglyza SAVOR-TIMI 53 type-2 diabetes outcomes study
  • Qtern (saxagliptin/dapagliflozin FDC) type-2 diabetes
  • Xigduo XR/Xigduo type-2 diabetes

Our medicines

Please note that the products mentioned may not be available in all countries. Additionally, currently approved indications (uses) and presentations may differ between countries. Country specific information is available from your local AstraZeneca company.

  • Atacand, Atacand HCT, Atacand Plus candesartan cilexetil
  • Brilinta/Brilique ticagrelor
  • Bydureon exenatide
  • Byetta exenatide injection
  • Crestor rosuvastatin
  • Farxiga/Forxiga dapagliflozin
  • Kombiglyze XR saxagliptin and metformin XR
  • Komboglyze saxagliptin and metformin HCl
  • Onglyza saxagliptin
  • Plendil, Modip, Splendil, Munobal, Flodil felodipine
  • Seloken ZOK, Toprol-XL, Betaloc ZOK metoprolol succinate
  • Symlin pramlintide acetate
  • Tenormin, Tenormine, Prenormine, Atenol atenolol
  • Zestril lisinopril dihydrate
  • XIGDUO dapagliflozin and metformin HCI
  • XIGDUO XR dapagliflozin and metformin HCI extended-release

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