Our pipeline

We have an exciting and balanced pipeline underpinned by great science.

Latest quarterly updates

Our pipeline forms a robust portfolio of investigational therapies in varied stages of clinical development.

164

projects in our pipeline

9

new molecular entities in our late-stage pipeline

1

new molecular entity approval in the last quarter

Phase III/LCM Projects: refers to assets that are pivotal in Phase II/III, or that have been submitted for regulatory approval, and may include assets that are now launched in one or more major markets (removed when launched in all applicable major markets).

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Oncology (as at 24 October 2019)

Phase I

Phase I

  • AZD1390 glioblastoma
  • AZD4573 haematalogical malignancies
  • AZD5153 solid tumours, haematological malignancies
  • AZD5991 haematalogical malignancies
  • AZD9496 oestrogen receptor +ve breast cancer
  • AZD9833 oestrogen receptor +ve breast cancer
  • Calquence + ceralasertib (AZD6738) haematological malignancies
  • Calquence + danvatirsen haematological malignancies
  • Imfinzi + adavosertib solid tumours
  • Imfinzi + RT (platform) CLOVER locally-advanced head and neck squamous cell carcinoma, non-small cell lung cancer, small-cell lung cancer
  • Imfinzi + selumetinib solid tumours
  • Imfinzi + tremelimumab solid tumours
  • Imfinzi + tremelimumab + CTx 1st-line pancreatic ductal adenocarcinoma, oesophageal and small cell lung cancer
  • MEDI1191 solid tumours
  • MEDI2228 multiple myeloma
  • MEDI5083 solid tumours
  • MEDI5752 solid tumours
  • MEDI7247 haematological malignancies, solid tumours
  • oleclumab + AZD4635 EGFRm NSCLC
  • oleclumab + Tagrisso EGFRm NSCLC

Phase II

Phase II

  • (oleclumab+CTx) or (Imfinzi+oleclumab+CTx) metastatic pancreatic cancer
  • adavosertib ovarian cancer, solid tumours
  • AZD2811 solid tumours, haematological malignancies
  • AZD4635 solid tumours
  • capivasertib breast cancer
  • capivasertib prostate cancer
  • Imfinzi (platform) COAST non small cell lung cancer
  • Imfinzi (platform) NeoCOAST non small cell lung cancer
  • Imfinzi + AZD4635 solid tumours
  • Imfinzi + AZD5069 or Imfinzi + danvatirsen head and neck squamous cell carcinoma, bladder and NSCLC
  • Imfinzi + FOLFOX + bevacizumab COLUMBIA 1 1st-line metastatic microsatellite-stable colorectal cancer
  • Imfinzi + Lynparza BAYOU 1st-line unresectable stage IV bladder cancer
  • Imfinzi + Lynparza ORION 1st-line metastatic non-small cell lung cancer
  • Imfinzi + MEDI0457 head and neck squamous cell carcinoma
  • Imfinzi + monalizumab solid tumours
  • Imfinzi + oleclumab solid tumours
  • Imfinzi + tremelimumab biliary tract, oesophageal
  • Imfinzi + tremelimumab gastric cancer
  • Lynparza + adavosertib solid tumours
  • Lynparza + ceralasertib (AZD6738) VIOLETTE breast cancer
  • Lynparza + Imfinzi MEDIOLA ovarian cancer, breast cancer, gastic cancer and small-cell lung cancer
  • oleclumab + AZD4635 prostate cancer
  • Tagrisso + or selumetinib or savolitinib) TATTON advanced EGFRm non-small cell lung cancer
  • Tagrisso + savolitinib SAVANNAH advanced EGFRm non-small cell lung cancer
  • trastuzumab deruxtecan HER2-expressing advanced colorectal cancer
  • trastuzumab deruxtecan HER2-Over-Expressing or -Mutated, Unresectable and/or Metastatic Non Small Cell Lung Cancer

Phase III

Phase III

  • capivasertib + CTx CAPItello-290 1st-line metastatic triple negative breast cancer
  • Imfinzi + tremelimumab DANUBE 1st-line bladder cancer
  • Imfinzi + tremelimumab HIMALAYA 1st-line hepatocellular carcinoma
  • Imfinzi + tremelimumab KESTREL 1st-line head and neck squamous cell carcinoma
  • Imfinzi + tremelimumab + SoC NILE 1st-line urothelial cancer
  • Imfinzi +/- tremelimumab + CRT ADRIATIC 1st-line limited-stage small-cell lung cancer
  • Imfinzi +/- tremelimumab + CTx POSEIDON 1st-line non-small cell lung cancer
  • Imfinzi +/- tremelimumab + SoC CASPIAN 1st-line extensive-stage small-cell lung cancer
  • Lumoxiti 3rd-line hairy cell leukaemia
  • Lynparza + Imfinzi + bevacizumab DUO-O 1st-line ovarian cancer
  • selumetinib SPRINT paediatric neurofibromatosis type-1
  • trastuzumab deruxtecan DESTINY-Breast03 HER2-positive, unresectable and/or metastatic breast cancer subjects previously treated with trastuzumab and taxane
  • trastuzumab deruxtecan DESTINY-Breast02 HER2-positive, Unresectable and/or Metastatic Breast Cancer Pretreated With Prior Standard of Care HER2 Therapies, Including T-DM1
  • trastuzumab deruxtecan DESTINY-Gastric01 HER2-overexpressing advanced gastric or gastroesophageal junction adenocarcinoma patients who have progressed on two prior treatment regimens
  • trastuzumab deruxtecan DESTINY-Breast01 HER2-Positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With T-DM1
  • trastuzumab deruxtecan DESTINY-Breast04 HER2-low, unresectable and/or metastatic breast cancer subjects

LCM Projects

LCM Projects

  • Calquence ECHO 1st-line mantle cell lymphoma
  • Calquence ASCEND relapsed/refractory chronic lymphocytic leukaemia
  • Calquence ELEVATE-RR relapsed/refractory chronic lymphocytic leukaemia, high risk
  • Calquence ELEVATE-TN 1st-line chronic lymphocytic leukaemia
  • Calquence + venetoclax + obinutuzumab 1st-line chronic lymphocytic leukaemia
  • Imfinzi CALLA locally-advanced cervical cancer
  • Imfinzi POTOMAC non muscle invasive bladder cancer
  • Imfinzi PACIFIC locally advanced (stage III) NSCLC
  • Imfinzi solid tumours
  • Imfinzi PEARL 1st-line metastatic non-small cell lung cancer
  • Imfinzi (platform) BEGONIA 1st-line metastatic triple negative breast cancer
  • Imfinzi (platform) MAGELLAN 1st-line metastatic non-small cell lung cancer
  • Imfinzi + azacitidine myelodysplastic syndrome
  • Imfinzi + CRT PACIFIC-2 locally-advanced (stage III) NSCLC
  • Imfinzi + CRT PACIFIC-5 (China) locally-advanced (stage III) NSCLC
  • Imfinzi + CTx NIAGARA muscle invasive bladder cancer
  • Imfinzi + CTx TOPAZ-1 1st-line biliary tract cancer
  • Imfinzi + CTx neoadjuvant AEGEAN locally-advanced (stage I-III) NSCLC
  • Imfinzi + VEGF EMERALD-2 adjuvant hepatocellar carcinoma
  • Imfinzi + VEGF + TACE EMERALD-1 locoregional hepatocellar carcinoma
  • Imfinzi post-SBRT PACIFIC-4 stage I/II non-small cell lung cancer
  • Lynparza PROfound prostate cancer
  • Lynparza SOLO-1 1st-line BRCAm ovarian cancer
  • Lynparza SOLO-2 2nd-line or greater BRCAm PSR ovarian cancer, maintenance monotherapy
  • Lynparza OlympiA gBRCA adjuvant breast cancer
  • Lynparza OlympiAD gBRCA metastatic breast cancer
  • Lynparza POLO pancreatic cancer
  • Lynparza SOLO-3 gBRCA PSR ovarian cancer
  • Lynparza (basket) MK-7339-002 / LYNK002 HRRm cancer
  • Lynparza + abiraterone PROpel prostate cancer
  • Lynparza + cediranib CONCERTO recurrent platinum-resistant ovarian cancer
  • Tagrisso ADAURA adjuvant EGFRm non-small cell lung cancer
  • Tagrisso FLAURA 1st-line advanced EGFRm non-small cell lung cancer
  • Tagrisso LAURA stage 3 EGFRm non-small cell lung cancer
  • Tagrisso + CTx FLAURA2 1st-line advanced EGFRm non-small cell lung cancer

Cardiovascular, Renal and Metabolism (as at 24 October 2019)

Phase I

Phase I

  • AZD6615 CV disease
  • AZD8233 CV disease
  • AZD9977 CV disease
  • MEDI6570 cardiovascular disease
  • MEDI7219 type-2 diabetes

Phase II

Phase II

  • AZD4831 heart failure with a preserved ejection fraction
  • AZD5718 coronary artery disease
  • AZD8601 cardiovascular disease
  • cotadutide type-2 diabetes and obesity
  • MEDI5884 cardiovascular disease
  • MEDI6012 cardiovascular disease
  • roxadustat chemotherapy induced anaemia
  • verinurad chronic kidney disease

Phase III

Phase III

  • Epanova severe hypertriglyceridaemia
  • Lokelma hyperkalaemia
  • roxadustat anaemia in myelodysplastic syndrome
  • roxadustat OLYMPUS ROCKIES anaemia in chronic kidney disease/end-stage renal disease

LCM Projects

LCM Projects

  • Brilinta/Brilique THALES acute ischaemic stroke or transient ischaemic attack
  • Brilinta/Brilique HESTIA prevention of vaso-occlusive crises in paediatric patients with sickle cell disease
  • Brilinta/Brilique THEMIS cardiovascular outcomes trial in patients with coronary artery disease and type-2 diabetes without a previous history of myocardial infarction or stroke
  • Bydureon EXSCEL type-2 diabetes outcomes study
  • Bydureon BCise (autoinjector) type-2 diabetes
  • Epanova STRENGTH cardiovascular outcomes study in statin-treated patients at high cardiovascular risk, with persistent hypertriglyceridemia plus low HDL-cholesterol
  • Farxiga/Forxiga Dapa-CKD renal outcomes and cardiovascular mortality in patients with chronic kidney disease
  • Farxiga/Forxiga Dapa-HF worsening heart failure or cardiovascular death in patients with chronic heart failure (HFrEF)
  • Farxiga/Forxiga DECLARE- TIMI 58 cardiovascular outcomes trial in patients with type-2 diabetes
  • Farxiga/Forxiga DELIVER worsening HF or CV death in patients with chronic heart failure (HFpEF)
  • Farxiga/Forxiga DEPICT type-1 diabetes
  • Farxiga/Forxiga DETERMINE-Preserved heart failure with preserved ejection fraction (HFpEF)
  • Farxiga/Forxiga DETERMINE-Reduced heart failure with reduced ejection fraction (HFrEF)
  • Qternmet XR/Qtrilmet (saxagliptin/dapagliflozin metformin) type-2 diabetes
  • Xigduo XR/Xigduo type-2 diabetes

Respiratory (as at 24 October 2019)

Phase I

Phase I

  • AZD0449 asthma
  • AZD1402 asthma
  • AZD5634 cystic fibrosis
  • AZD8154 asthma
  • MEDI3506 chronic obstructive pulmonary disease

Phase II

Phase II

  • abediterol asthma/chronic obstructive pulmonary disease
  • AZD7594 asthma/chronic obstructive pulmonary disease
  • AZD7986 chronic obstructive pulmonary disease
  • AZD8871 chronic obstructive pulmonary disease
  • AZD9567 rheumatoid arthritis/respiratory
  • Breztri Aerosphere (PT010) asthma
  • tezepelumab atopic dermatitis
  • tezepelumab chronic obstructive pulmonary disease

Phase III

Phase III

  • Bevespi Aerosphere (PT003) chronic obstructive pulmonary disease
  • Breztri Aerosphere (PT010) chronic obstructive pulmonary disease
  • Fasenra CALIMA SIROCCO ZONDA BISE BORA GREGALE severe uncontrolled asthma
  • PT027 asthma
  • tezepelumab NAVIGATOR SOURCE severe uncontrolled asthma

LCM Projects

LCM Projects

  • Duaklir Genuair chronic obstructive pulmonary disease
  • Fasenra OSTRO nasal polyposis
  • Fasenra RESOLUTE chronic obstructive pulmonary disease
  • Symbicort SYGMA as-needed use in mild asthma

Other (as at 24 October 2019)

Phase I

Phase I

  • AZD0284 psoriasis/respiratory
  • MEDI1341 parkinson's disease
  • MEDI1814 alzheimer’s disease
  • MEDI5117 China rheumatoid arthritis

Phase II

Phase II

  • anifrolumab lupus nephritis
  • anifrolumab systemic lupus erythematosus (subcutaneous)
  • MEDI3902 prevention of nosocomial Pseudomonas aeruginosa pneumonia
  • MEDI7352 osteoarthritis pain and painful diabetic neuropathy
  • suvratoxumab prevention of nosocomial Staphylococcus aureus pneumonia

Phase III

Phase III

  • anifrolumab TULIP systemic lupus erythematosus
  • nirsevimab (MEDI8897) passive RSV immunisation

LCM Projects

LCM Projects

  • Linzess irritable bowel syndrome with constipation (IBS-C)
  • Nexium stress ulcer prophylaxis

Terminations

  • savolitinib SAVOIR papillary renal cell carcinoma
  • AZD1419 asthma
  • MEDI8852 influenza A treatment
  • Imfinzi + tremelimumab NEPTUNE 1st-line non-small cell lung cancer
  • MEDI0700 systemic lupus erythematosus

Veeva ID: Z4-12937     
Date of next review: September 2020