Publications

R&D / Early Discovery

31 July 2019 Details

Published:

Science Advances

Author(s):

Jenny Sandmark Show all authors Janna Bigalke, Goran Dahl, Euan Gordon, Robert Roth

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Cryo-electron microscopy

RIA /Early Discovery

01 July 2019 Details

Published:

Nature Immunology

Author(s):

Yoichiro Ohne Show all authors Alison Humbles, Jingya Wang, Jinchneg Wu

R&D / Early Discovery

13 June 2019 Details

Published:

Nature Communications

Author(s):

Ralph Minter Show all authors Jason Breed, Judit Debreczeni, Christopher Stubbs, Jonathan Tart

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Using novel tools to inhibit challenging targets

CVRM / Early Discovery

10 June 2019 Details

Published:

Journal of the American College of Cardiology

Author(s):

Li-Ming Gan

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Video – The heritability of coronary artery disease

Pharm Sci / Early Discovery

22 April 2019 Details

Published:

Nature Chemistry

Author(s):

James Douglas

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Lighting the path to simplified chemical reactions

R&D /Early Discovery

19 April 2019 Details

Published:

Science

Author(s):

Pinar Akcakaya Show all authors Marcello Maresca, Michelle Porritt, Michaela Morlock

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Video – Monitoring CRISPR gene editing in vivo

CVRM / Early Discovery

28 March 2019 Details

Published:

Cell Stem Cell

Author(s):

Qing-Dong Wang Show all authors Aurelie Bornot, Mei Ding, Henrik Andersson, Magnus Polla, Lauren Drowley, Maryam Clausen, Alleyn T Plowright, Ian Barrett

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Video – Stimulating cardiac cell growth

Respiratory

07 March 2019 Details

Published:

Communications Biology

Author(s):

Gabriela Marchetti, Timothy Burwell, Norman Peterson, Jennifer Cann, Richard Hanna, Qing Li, Emily Ongstad, Jonathan Boyd, Maureen Kennedy, Weiguang Zhao, Keith Rickert, Joseph Grimsby, William Dall’Acqua, Herren Wu, Ping Tsui, Jack Borrok, Ruchi Gupta

Oncology

28 February 2019 Details

Published:

Nature Reviews Clinical Oncology

Author(s):

Andrew Reynolds, Elizabeth Kuczynski

R&D / Early Discovery

25 February 2019 Details

Published:

Nature Structural & Molecular Biology

Author(s):

Emanuela Cuomo Show all authors Ben Taylor

CVRM, Early Discovery

20 February 2019 Details

Published:

Nature Communications

Author(s):

Li-Ming Gan, Lagerström-Fermér M, Carlsson L, Arfvidsson C, Egnell A-C, Rudvik A, Kjaer M, Fritsche-Danielson R

Related content

Designing the first-ever trial for an mRNA-based therapeutic

Oncology

18 February 2019 Details

Published:

Nature Immunology

Author(s):

Philip Brohawn, Brandon Higgs

Early Discovery

04 February 2019 Details

Published:

Nature Chemical Biology

Author(s):

Jens Petersen, Gangadhara Gangadhara, Göran Dahl, Jens Petersen, Rebecca Rae, Jenny Gunnarsson, Stefan Blaho, Linda Öster, Helena Lindmark, Kostas Karabelas, Nils Pemberton, Christian Tyrchan, Matthew Perry, Tineke Papavoine, Michael Mogemark

CVRM, Early Discovery

30 January 2019 Details

Published:

Nature

Author(s):

Stefano Bartesaghi, Henrik Palmgrem, Xioa-Rong Peng

Respiratory

29 January 2019 Details

Published:

Immunity

Author(s):

Benjamin Kemp, Matthew Robinson

Oncology

08 January 2019 Details

Published:

Nature Communications

Author(s):

Josep Forment, Stephen Durant

Discovery Sciences / Early Discovery

02 January 2019 Details

Published:

Nature Communications

Author(s):

Catherine Bardelle, Ulf Borjesson, Matther Collier, Paul Harper, Darren Plant, Helen Plant, Mark Wigglesworth, Roger Clark, Kirsty Rich

Precision Medicines & Genomics

26 December 2018 Details

Published:

The New England Journal of Medicine

Author(s):

Adam Platt, Sophia Cameron-Christie, Jan Fleckner, Slavé Petrovski, Carolina Haefliger, Ruth March

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The dawn of a new era in chronic kidney disease

Oncology

17 December 2018 Details

Published:

Nature Communications

Author(s):

Adriana Tron, Ammar Adam, Brian Aquila, Mathew Belmonte, Elisabetta Chiarparin, Justin Cidado, Kevin Embrey, Eric Gangl, Frank Giboons, David Hargreaves, Adam Hendricks, Alex Hird, Jeffrey Johannes, Jason Kettle, Michelle Lamb, Martin Packer, Bo Peng, Phillip Rawlins, Alwin Schuller, Paul Secrist, Nancy Su, David Wilson, Wenzhen Yang, Ye Qing, XiaoLan Zheng, Steven Kazmirski, Daniel Robbins, Ed Clarke, Stephen Fawell

CVRM, Early Discovery

18 December 2018 Details

Published:

Circulation

Author(s):

Qing-Dong Wang

Related content

Uncovering the right targets: Refining cardiovascular regenerative medicine

Pharm Sci

10 December 2018 Details

Published:

Nature Catalysis

Author(s):

Per-Ola Norrby, Elaine Limé

CVRM, Early Discovery

03 December 2018 Details

Published:

Nature Metabolism

Author(s):

Stefan Hallén, Matthew Harms

Oncology

18 October 2018 Details

Published:

Cancer Discovery

Author(s):

Jon Travers, Simon Barry, Kim Maratea, Paula Taylor, Elizabeth Pease

CVRM, Early Discovery

22 October 2018 Details

Published:

Nature Catalysis

Author(s):

Ulrik Jurva, Justyna Kulig, Shalini Andersson, Emre Isin

CVRM, Early Discovery

17 October 2018 Details

Published:

Science Advances

Author(s):

Carina Ämmälä, William J Drury III, Laurent Knerr, Ingela Ahlstedt, Pia Stillemark-Billton, Charlotte Wennberg-Huldt, Eva-Marie Andersson, Eric Valeur, Rasmus Jansson-Löfmark, David Janzén, Linda Sundström, Johan Meuller, Josefine Claesson, Patrik Andersson, Camilla Johansson, Shalini Andersson

Related content

AstraZeneca shows potential of gene silencing in pancreatic cells

Scientific Partnering & Alliances

12 October 2018 Details

Published:

Nature Reviews Drug Discovery

Author(s):

Jane Escott

CVRM, Early Discovery

12 September 2018 Details

Published:

Nature Catalysis

Author(s):

Joakim Bergman, Andrei Iosub

Discovery Sciences, Early Discovery

12 September 2018 Details

Published:

Nature

Author(s):

Pinar Akcakaya, Mick Fellows, Michelle Porritt, Mike Firth, Alba Carreras, Frank Seeliger, Mikael Bjursell, Roberto Nitsch, Mohammad Bohlooly, Marcello Maresca, Tania Baccega, Lorenz May

Respiratory

04 October 2018 Details

Published:

European Heart Journal, ehy531,https://doi.org/10.1093/eurheartj/ehy531

Author(s):

Lynne Murray

CVRM

27 August 2018 Details

Published:

European Heart Journal, ehy531,https://doi.org/10.1093/eurheartj/ehy531

Author(s):

Li-Ming Gan Show all authors Malin Broberg, Maria Lagerstrom-Fermer.

Related content

A PROMISing future: New insights to disease drivers and potential new diagnostic markers in heart disease

CVRM

24 August 2018 Details

Published:

Nature Reviews Drug Discovery

Author(s):

Jonas Boström Show all authors Dean Brown

CVRM

09 August 2018 Details

Published:

European Heart Journal, ehy419,https://doi.org/10.1093/eurheartj/ehy419

Author(s):

Erik Michaëlsson Show all authors Eva-Lotte Lindstedt

Related content

A PROMISing future: New insights to disease drivers and potential new diagnostic markers in heart disease

Early Development

03 August 2018 Details

Published:

2018. American Journal of Respiratory and Critical Care Medicine. 1 Oct 2018; 198(7):928-940. doi: 10.1164/rccm.201706-1110OC.

Author(s):

Han Si, Rebecca Halpin, Todd Creasy, Claudie Bantsimba-Malanda, Ron Herbst

CVRM, Early Discovery

02 August 2019 Details

Published:

EBioMedicine

Author(s):

Wiseman, John W

CVRM

23 June 2018 Details

Published:

Published online 22 Jun 2018: Lancet. doi:10.1016/S0140-6736(18)30726-8.

Author(s):

Philip Ambery, Victoria Parker, Lan-Feng Tsai, Darren Robertson, Meena Jain, Marcella Petrone, Cristina Rondinone, Boaz Hirshberg, Lutz Jermutus

Oncology

20 June 2018 Details

Published:

Science Advances 20 Jun 2018: Vol. 4, no. 6, eaat1719 DOI: 10.1126/sciadv.aat1719

Author(s):

Durant, Stephen Show all authors Pass, Martin Riches, Lucy Garcia-Trinidad, Antonio Fok, Jacqueline Hunt, Thomas Pike, Kurt G Wilson, Joanne Smith, Aaron Colclough, Nicola Pilla Reddy, Venkatesh Sykes, Andy Janefeldt, Annika Johnström, Peter Ling, Stephanie Orme, Jonathon Barrett, Ian Jones, Gemma Roudier, Martine Pierce, Andrew Cronin, Anna Chapman, Melissa Illingworth, Ruth

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Preclinical data of the ATM inhibitor, AZD1390 show promising results in brain tumour models

Publications

Commitment to science

Our commitment to science is reflected in our track record of publications. Here are a few recent examples of high impact publications co-authored by AstraZeneca scientists.

Cryo EM structure of the activated RET signalling complex reveals the importance of its cysteine rich domain

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

Selective inhibition of KRAS-effector interaction by a DARPin-induced allosteric conformational change

Major contribution of regulatory-gene networks to coronary artery disease heritability

Practical and regioselective amination of arenes using alkyl amines

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway

Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis

Vessel co-option in cancer

DNA stretching induces Cas9 off-target activity

Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes

The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity

A class of highly selective inhibitors bind to an active state of PI3Kγ

Foxk1/Foxk2 regulate aerobic glycolysis

Microbiota sensing by Mincle-Syk Axis in dendritic cells regulates interleukin-17 and -22 production and promotes intestinal barrier integrity

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Diagnostic utility of exome sequencing for kidney disease

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Fate mapping of sca1+ cardiac progenitor cells in the adult mouse heart

CatVS: rapid virtual screening of enantioselective catalysts

Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity

Cells lacking the RB1 tumour suppressor gene are hyperdependent on Aurora B kinase for survival

Engineering highly functional thermostable proteins using ancestral sequence reconstruction

Targeted delivery of antisense oligonucleotides to pancreatic ß-cells

Drug repurposing: progress, challenges and recommendations

Celebrating 100 years of the Rosenmund reaction

In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations

Targeting of TAM receptors ameliorates fibrotic mechanisms in idiopathic pulmonary fibrosis

Prevalence and correlates of cardiac microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

Expanding the medicinal chemistry toolbox: a perspective on the impact of synthetic chemistry methodologies in drug discovery

Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilisation of high-risk atherosclerotic plaque

Impaired tumor-infiltrating T cells in patients with chronic obstructive pulmondary disease impact lung cancer response to PD-1 blockade

Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype

MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models