Publications

Commitment to science

Our commitment to science is reflected in our track record of publications. Here are a few recent examples of high impact and high quality publications co-authored by AstraZeneca and/or MedImmune scientists.

Oncology


An analysis of the attrition of drug candidates from four major pharmaceutical companies

PUBLISHED
In press, published online 19 June 2015: 2015 Nature Reviews Drug Discovery 14, 475–486 (2015) doi:10.1038/nrd4609

AREA
Oncology

ASTRAZENECA/MEDIMMUNE AUTHOR
Mike Waring (Oncology iMed)


MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis

PUBLISHED
May 2015: Nat Commun. 2015;6(7096). doi:10.1038/ncomms8096.

AREA
Oncology

ASTRAZENECA/MEDIMMUNE AUTHOR
Zheng Liu, Wei Zhu, Yue Wang, Bo Chen, Ronald Herbst, Laura Richman, Bahija Jallal, Yihong Yao (MedImmune)


Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M

PUBLISHED
Published online 04 May 2015: Nature Medicine 21,560–562(2015) doi:10.1038/nm.3854

AREA
Oncology

ASTRAZENECA/MEDIMMUNE AUTHOR
Kenneth Tress (Oncology iMed)


Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations

PUBLISHED
May 2015: Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

AREA
Oncology

ASTRAZENECA/MEDIMMUNE AUTHOR
Brandon Higgs (MedImmune)


Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ

PUBLISHED
January 2015: Cancer Cell. 2015 Jan 12;27(1):109-22. doi: 10.1016/j.ccell.2014.11.008.

AREA
Oncology iMed

ASTRAZENECA/MEDIMMUNE AUTHOR
Simon Barry (Oncology iMed)


Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

PUBLISHED
January 2015:Cancer Cell. 2015 Jan 12;27(1):57-71. doi: 10.1016/j.ccell.2014.12.002.

AREA
Oncology

ASTRAZENECA/MEDIMMUNE AUTHOR
Susan Critchlow (Oncology iMed)


Cardiovascular and Metabolic diseases


C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions

PUBLISHED
January 2015: Cancer Cell. 2015 Jan 12;27(1):109-22. doi: 10.1016/j.ccell.2014.11.008.

AREA
Cardiovascular and Metabolic Disease

ASTRAZENECA/MEDIMMUNE AUTHOR
Alex Zhou (CVMD iMed)


Respiratory, Inflammation and Autoimmunity


TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

PUBLISHED
July 2015: Nat Immunol. 2015;16(9):970-979. doi:10.1038/ni.3211.

AREA
Respiratory, Inflammation and Autoimmunity

ASTRAZENECA/MEDIMMUNE AUTHOR
Yong-Jun Liu (MedImmune)


Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy

PUBLISHED
May 2015: Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

AREA
Inflammation and Autoimmunity

ASTRAZENECA/MEDIMMUNE AUTHOR
Tomas Mustelin (MedImmune)


IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk

PUBLISHED
May 2015: Allergy, Volume 70, Issue 5, pages 556–567. doi: 10.1111/all.12593

AREA
Respiratory, Inflammation and Autoimmunity

ASTRAZENECA/MEDIMMUNE AUTHOR
Richard May (MedImmune)


Neuroscience


KCC2 activity is critical in limiting the onset and severity of status epilepticus

PUBLISHED
March 2015: Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3523-8. doi: 10.1073/pnas.1415126112.

AREA
Neuroscience

ASTRAZENECA/MEDIMMUNE AUTHOR
Nick Brandon (Neuroscience iMed)

Infection and Vaccines


Palivizumab epitope–displaying virus-like particles protect rodents from RSV challenge

PUBLISHED
March 2015: J Clin Invest. 2015;125(4):1637–1647. doi:10.1172/JCI78450.

AREA
Infection and Vaccines

ASTRAZENECA/MEDIMMUNE AUTHOR
Jeanne H. Schickli, Roderick S. Tang, Jasmine Kaur, Heather Lawlor, Michael P. McCarthy, Gary Van Nest (MedImmune)