Publications

Pharm Sci / Early Discovery

22 April 2019 Details

Published:

Nature Chemistry

Author(s):

James Douglas

R&D /Early Discovery

19 April 2019 Details

Published:

Science

Author(s):

Pinar Akcakaya Show all authors Marcello Maresca, Michelle Porritt, Michaela Morlock

CVRM / Early Discovery

28 March 2019 Details

Published:

Cell Stem Cell

Author(s):

Qing-Dong Wang Show all authors Aurelie Bornot, Mei Ding, Henrik Andersson, Magnus Polla, Lauren Drowley, Maryam Clausen, Alleyn T Plowright, Ian Barrett

Respiratory

07 March 2019 Details

Published:

Communications Biology

Author(s):

Gabriela Marchetti, Timothy Burwell, Norman Peterson, Jennifer Cann, Richard Hanna, Qing Li, Emily Ongstad, Jonathan Boyd, Maureen Kennedy, Weiguang Zhao, Keith Rickert, Joseph Grimsby, William Dall’Acqua, Herren Wu, Ping Tsui, Jack Borrok, Ruchi Gupta

Oncology

28 February 2019 Details

Published:

Nature Reviews Clinical Oncology

Author(s):

Andrew Reynolds, Elizabeth Kuczynski

R&D / Early Discovery

25 February 2019 Details

Published:

Nature Structural & Molecular Biology

Author(s):

Emanuela Cuomo Show all authors Ben Taylor

CVRM, Early Discovery

20 February 2019 Details

Published:

Nature Communications

Author(s):

Li-Ming Gan, Lagerström-Fermér M, Carlsson L, Arfvidsson C, Egnell A-C, Rudvik A, Kjaer M, Fritsche-Danielson R

Oncology

18 February 2019 Details

Published:

Nature Immunology

Author(s):

Philip Brohawn, Brandon Higgs

Early Discovery

04 February 2019 Details

Published:

Nature Chemical Biology

Author(s):

Jens Petersen, Gangadhara Gangadhara, Göran Dahl, Jens Petersen, Rebecca Rae, Jenny Gunnarsson, Stefan Blaho, Linda Öster, Helena Lindmark, Kostas Karabelas, Nils Pemberton, Christian Tyrchan, Matthew Perry, Tineke Papavoine, Michael Mogemark

CVRM, Early Discovery

30 January 2019 Details

Published:

Nature

Author(s):

Stefano Bartesaghi, Henrik Palmgrem, Xioa-Rong Peng

Respiratory

29 January 2019 Details

Published:

Immunity

Author(s):

Benjamin Kemp, Matthew Robinson

Oncology

08 January 2019 Details

Published:

Nature Communications

Author(s):

Josep Forment, Stephen Durant

Discovery Sciences / Early Discovery

02 January 2019 Details

Published:

Nature Communications

Author(s):

Catherine Bardelle, Ulf Borjesson, Matther Collier, Paul Harper, Darren Plant, Helen Plant, Mark Wigglesworth, Roger Clark, Kirsty Rich

Precision Medicines & Genomics

26 December 2018 Details

Published:

The New England Journal of Medicine

Author(s):

Adam Platt, Sophia Cameron-Christie, Jan Fleckner, Slavé Petrovski, Carolina Haefliger, Ruth March

Oncology

17 December 2018 Details

Published:

Nature Communications

Author(s):

Adriana Tron, Ammar Adam, Brian Aquila, Mathew Belmonte, Elisabetta Chiarparin, Justin Cidado, Kevin Embrey, Eric Gangl, Frank Giboons, David Hargreaves, Adam Hendricks, Alex Hird, Jeffrey Johannes, Jason Kettle, Michelle Lamb, Martin Packer, Bo Peng, Phillip Rawlins, Alwin Schuller, Paul Secrist, Nancy Su, David Wilson, Wenzhen Yang, Ye Qing, XiaoLan Zheng, Steven Kazmirski, Daniel Robbins, Ed Clarke, Stephen Fawell

CVRM, Early Discovery

18 December 2018 Details

Published:

Circulation

Author(s):

Qing-Dong Wang

Pharm Sci

10 December 2018 Details

Published:

Nature Catalysis

Author(s):

Per-Ola Norrby, Elaine Limé

CVRM, Early Discovery

03 December 2018 Details

Published:

Nature Metabolism

Author(s):

Stefan Hallén, Matthew Harms

Oncology

18 October 2018 Details

Published:

Cancer Discovery

Author(s):

Jon Travers, Simon Barry, Kim Maratea, Paula Taylor, Elizabeth Pease

CVRM, Early Discovery

22 October 2018 Details

Published:

Nature Catalysis

Author(s):

Ulrik Jurva, Justyna Kulig, Shalini Andersson, Emre Isin

CVRM, Early Discovery

17 October 2018 Details

Published:

Science Advances

Author(s):

Carina Ämmälä, William J Drury III, Laurent Knerr, Ingela Ahlstedt, Pia Stillemark-Billton, Charlotte Wennberg-Huldt, Eva-Marie Andersson, Eric Valeur, Rasmus Jansson-Löfmark, David Janzén, Linda Sundström, Johan Meuller, Josefine Claesson, Patrik Andersson, Camilla Johansson, Shalini Andersson

Scientific Partnering & Alliances

12 October 2018 Details

Published:

Nature Reviews Drug Discovery

Author(s):

Jane Escott

CVRM, Early Discovery

12 September 2018 Details

Published:

Nature Catalysis

Author(s):

Joakim Bergman, Andrei Iosub

Discovery Sciences, Early Discovery

12 September 2018 Details

Published:

Nature

Author(s):

Pinar Akcakaya, Mick Fellows, Michelle Porritt, Mike Firth, Alba Carreras, Frank Seeliger, Mikael Bjursell, Roberto Nitsch, Mohammad Bohlooly, Marcello Maresca, Tania Baccega, Lorenz May

Early Development

03 August 2018 Details

Published:

2018. American Journal of Respiratory and Critical Care Medicine. 1 Oct 2018; 198(7):928-940. doi: 10.1164/rccm.201706-1110OC.

Author(s):

Han Si, Rebecca Halpin, Todd Creasy, Claudie Bantsimba-Malanda, Ron Herbst

Respiratory

04 October 2018 Details

Published:

European Heart Journal, ehy531,https://doi.org/10.1093/eurheartj/ehy531

Author(s):

Lynne Murray

CVRM

27 August 2018 Details

Published:

European Heart Journal, ehy531,https://doi.org/10.1093/eurheartj/ehy531

Author(s):

Li-Ming Gan Show all authors Malin Broberg, Maria Lagerstrom-Fermer.

Related Articles

A PROMISing future: New insights to disease drivers and potential new diagnostic markers in heart disease

CVRM

24 August 2018 Details

Published:

Nature Reviews Drug Discovery

Author(s):

Jonas Boström Show all authors Dean Brown

CVRM

09 August 2019 Details

Published:

European Heart Journal, ehy419,https://doi.org/10.1093/eurheartj/ehy419

Author(s):

Erik Michaëlsson Show all authors Eva-Lotte Lindstedt

Related Articles

A PROMISing future: New insights to disease drivers and potential new diagnostic markers in heart disease

Neuroscience

07 August 2019 Details

Published:

Nature Communications volume 9, Article number: 3130 (2018)

Author(s):

Nick Brandon Show all authors Stephen J Moss

CVRM, Early Discovery

02 August 2019 Details

Published:

EBioMedicine

Author(s):

Wiseman, John W

Neuroscience

26 July 2018 Details

Published:

Nature Neuroscience volume 21, pages1117–1125 (2018)

Author(s):

Nick Brandon

CVRM

23 June 2018 Details

Published:

Published online 22 Jun 2018: Lancet. doi:10.1016/S0140-6736(18)30726-8.

Author(s):

hilip Ambery, Victoria Parker, Lan-Feng Tsai, Darren Robertson, Meena Jain, Marcella Petrone, Cristina Rondinone, Boaz Hirshberg, Lutz Jermutus

Oncology

20 June 2018 Details

Published:

Science Advances 20 Jun 2018: Vol. 4, no. 6, eaat1719 DOI: 10.1126/sciadv.aat1719

Author(s):

Durant, Stephen Show all authors Pass, Martin Riches, Lucy Garcia-Trinidad, Antonio Fok, Jacqueline Hunt, Thomas Pike, Kurt G Wilson, Joanne Smith, Aaron Colclough, Nicola Pilla Reddy, Venkatesh Sykes, Andy Janefeldt, Annika Johnström, Peter Ling, Stephanie Orme, Jonathon Barrett, Ian Jones, Gemma Roudier, Martine Pierce, Andrew Cronin, Anna Chapman, Melissa Illingworth, Ruth

Related Articles

Preclinical data of the ATM inhibitor, AZD1390 show promising results in brain tumour models

Oncology

10 May 2018 Details

Published:

The Lancet. doi.org/10.1016/S0140-6736(18)30789-X

Author(s):

Angell, Helen K

Related Articles

Helen Angell - Principal Scientist, Oncology, Translational Sciences, IMED Biotech Unit

CVRM

11 April 2018 Details

Published:

JAMA Cardiol. Published online April 11, 2018. doi:10.1001/jamacardio.2018.0618

Author(s):

Knöll, Ralph Show all authors Fritsche-Danielson, Regina Bhat, Ratan

Early Discovery

29 March 2018 Details

Published:

Nature Chemistry volume 10, pages383–394 (2018)

Author(s):

Wilson, David M

Oncology

12 March 2018 Details

Published:

Cancer Cell. doi.org/10.1016/j.ccell.2018.01.019

Author(s):

Chen, Raymond (Huawei) Show all authors Hattersley, Maureen O'Connor, Mark J (Cambridge) Fawell, Stephen

Early Discovery

23 March 2018 Details

Published:

Nature Reviews Drug Discovery volume 17,pages 317–332 (2018)

Author(s):

Muthas, Daniel

Oncology

09 March 2018 Details

Published:

Nature Reviews Cancer volume 18, pages 323–336 (2018)

Author(s):

Reynolds, Andrew R Show all authors Kuczynski, Elizabeth

RIA

10 January 2018 Details

Published:

The Lancet Respiratory Medicine. doi.org/10.1016/S2213-2600(18)30006-7

Author(s):

Rennard, Stephen I Show all authors Fagerås, Malin De Blas, Miguel Angel Richter, Kai

RIA

07 March 2018 Details

Published:

2018. Science Translational Medicine. 7 Mar 2018; 10(431). doi:10.1126/scitranslmed.aaf5307.

Author(s):

Devon Taylor, Nanette Mittereder, Ellen Kuta, Tracy Delaney, Timothy Burwell, Karma Dacosta, Weiguang Zhao, Lily Cheng, Charles Brown, Anmarie Boutrin, Xiang Guo, Wendy White, Jie Zhu, Huifang Dong, Michael Bowen, Jia Lin, Changshou Gao, Li Yu, Madhu Ramaswamy, Marie-Claude Gaudreau, Rob Woods, Ronald Herbst, Gianluca Carlesso

Infection

23 January 2018 Details

Published:

Published 2018. Clinical and Translational Immunology. 23 Jan 2018; 7(1):e1009. doi: 10.1002/cti2.1009.

Author(s):

Alexey Ruzin, Yuling Wu, Li Yu, Xiang-Qing Yu, David Tabor, Hoyin Mok, Christine Tkaczyk, Kathryn Jensen, Terramika Bellamy, Lorin Roskos, Mark Esser, Hasan Jafri

Early Discovery

22 January 2018 Details

Published:

Published online 22 Jan 2018: Communications Biology. doi:10.1038/s42003-017-0006-2.

Author(s):

Saravanan Rajan, Michael Kierny, Andrew Mercer, Jincheng Wu, Andrey Tovchigrechko, Herren Wu, William Dall'Acqua, Xiaodong Xiao, Partha Chowdhury

CVRM

07 December 2017 Details

Published:

Published online 6 Dec 2017: Cell Metabolism. doi: 10.1016/j.cmet.2017.10.016.

Author(s):

Maria Bednarek, Lutz Jermutus, Joseph Grimsby, Cristina Rondinone, Anish Konkar

Infection

08 December 2017 Details

Published:

2017. Nature Communications. 8 Dec 2017; 8(1):1991. doi: 10.1038/s41467-017-02223-7.

Author(s):

Meghan Pennini, Mark Pelletier, Jessica Bonnell, Romana Cvitkovic, Wei Zhao, Xiaodong Xiao, Maria Camara, Antonio DiGiandomenico, Elena Semenova, Paul Warrener, JoAnn Suzich, Qun Wang, Ken Stover

Early Discovery

08 December 2017 Details

Published:

Nature Reviews Drug Discovery. Published online 8th December 2017 doi:10.1038/nrd.2017.226

Author(s):

Platt, Adam, Goldstein, David

Neuroscience

07 December 2017 Details

Published:

Nature Medicine. Published online 7th December 2017 doi:10.1038/nm.4442

Author(s):

Brandon, Nicholas J. Show all authors McWilliams, Lisa, Burnham, Matthew, Baker, David, Dekker, Niek, Deeb, Tarek, Wang, Qi, Wobst, Heike

Related Articles

KCC2: unlocking the secrets of ‘over excited’ nerves

Respiratory

01 December 2017 Details

Published:

Science Immunology. Published online 1st December 2017 DOI: 10.1126/sciimmunol.aam9169

Author(s):

Krishnaswamy, Kumar, Mattsson, Johan

Related Articles

Specifying the role of the immune system's sentry guards

Early Discovery

01 December 2017 Details

Published:

Nature Reviews Drug Discovery. Published online 1st December 2017 doi:10.1038/nrd.2017.219

Author(s):

Holdgate, Geoff, Grimley, Rachel

Respiratory

21 November 2017 Details

Published:

Immunity. Published online 21 November 2017 http://dx.doi.org/10.1016/j.immuni.2017.10.017

Author(s):

Smith, David M

Early Discovery

20 November 2017 Details

Published:

Nature Communications 8. Published online 20th November 2017 doi:10.1038/s41467-017-01732-9

Author(s):

Taylor, Benjamin J, Bista, Michal J, Cuomo, Emanuela M Show all authors Gordon, Euan, Read, Jon A, Wrigley, Jonathan D

CVRM

13 November 2017 Details

Published:

Nature Medicine Published online: 13 November 2017 doi:10.1038/nm.4437

Author(s):

Wang, Qing-Dong

Oncology

02 November 2017 Details

Published:

Nature Protocols 12, 2465–2477 (2017) Published online 02 November 2017 doi:10.1038/nprot.2017.118

Author(s):

Karp, Natasha

CVRM

26 October 2017 Details

Published:

The British Medical Journal, 2017;359, doi: 10.1136/bmj.j4511

Author(s):

Gabra, Hani

CVRM

19 October 2017 Details

Published:

Cell, 171, 1–12, November 2, 2017, doi.10.1016/j.cell.2017.09.045

Author(s):

Lindén, Daniel Show all authors Elke Ericson, Tyrell Norris, Anders Johansson

Related Articles

Balancing FOXO1 inhibition opens up a new target in diabetes

Oncology

19 October 2017 Details

Published:

The Lancet Respiratory Medicine, published online October 19 2017, doi.10.1016/ S2213-2600(17)30378-8

Author(s):

Yang, Pamela Show all authors Sarit Cohen-Rabbie, Bryony Harrop, Philip Overend

Oncology

19 October 2017 Details

Published:

Cell, published online ahead of print 19 October 2017, doi: 10.1016/j.molcel.2017.09.024

Author(s):

Cosulich, Sabina C Show all authors Barneda Ciurana, David

Related Articles

New research reveals missing link between tumour suppressors and prostate cancer

Early Discovery

16 October 2017 Details

Published:

Nature Methods, published online ahead of print 16 October 2017, doi:10.1038/nmeth.4466

Author(s):

Nitsch, Roberto

Related Articles

Barcoding CRISPR/Cas9 improves the search for novel drug targets

Early Discovery

13 October 2017 Details

Published:

Nature Reviews Drug Discovery, published online ahead of print, doi:10.1038/nrd.2017.177

Author(s):

Greene, Nigel

Early Discovery

22 September 2017 Details

Published:

Nature Reviews Drug Discovery, published online ahead of print 22 September 2017, doi:10.1038/nrd.2017.146

Author(s):

Davis, Andy Show all authors Valeur, Eric

Early Discovery

20 December 2016 Details

Published:

Nature, published online ahead of print 20 September 2017, doi:10.1038/nature24016

Author(s):

CVRM

15 August 2017 Details

Published:

Cell Research. 2017; 27: 1157-1177. doi:10.1038/cr.2017.103

Author(s):

Wang, Qing-Dong

CVRM

15 August 2017 Details

Published:

JAMA. 2017;318(7):637-646. doi:10.1001/jama.2017.10169

Author(s):

Vaag, Allan

CVRM

20 July 2017 Details

Published:

Nature Communications, published online ahead of print 20 July 2017, doi:10.1038/s41467-017-00118-1

Author(s):

Wang, Qing-Dong

Oncology

14 July 2017 Details

Please read the related article 'Finding a cancer ‘off switch’ for mutant Ras' by clicking on the link below.

Published:

Nature Communications, published online ahead of print 14 July 2017, DOI: 10.1038/ncomms16111

Author(s):

Guillard, Sandrine; Minter, Ralph; Phillips, Christopher Show all authors Breed, Jason; Debreczeni, Judit; Overman, Ross; Tart, Jonathan; Kolasinska-Zwierz, Paulina; Marwood, Rose

Finding a cancer ‘off switch’ for mutant Ras

Early Discovery

30 June 2017 Details

Published:

Nature Biotechnology, published online ahead of print 30 June 2017, doi:10.1038/nmicrobiol.2017.104

Author(s):

Gao, Ning

Respiratory

28 June 2017 Details

Published:

The Lancet Respiratory Medicine, published online ahead of print 28 June 2017, DOI: 10.1016/S2213-2600(17)30207-2

Author(s):

Rennard, Stephen I

Early Discovery

26 June 2017 Details

Published:

Nature Communications, published online 26 June 2017, doi:10.1038/ncomms15475

Author(s):

Karp, Natasha

Oncology

23 June 2017 Details

Published:

Journal of Clinical Oncology, published online ahead of print 23 June 2017, DOI: 10.1200/JCO.2017.72.2967

Author(s):

Morgan, Shethah R; Frigault, Melanie Show all authors Clark, Edwin; Handzel, Amir

Oncology

14 June 2017 Details

Please read the related article 'Switching the light off in the discovery of new cancer therapies against KRAS' by clicking on the link below.

Published:

Science Translational Medicine, published 14 June 2017, DOI: 10.1126/scitranslmed.aal5253

Author(s):

Ross, Sarah; Lyne, Paul; Rooney, Claire; Hanson, Lyndsey L Show all authors Ellston, Rebecca A; Klein, Stephanie; Staniszewska, Anna D; Whalley, Nichola M

Switching the light off in the discovery of new cancer therapies against KRAS

Respiratory

01 June 2017 Details

Please read the related article 'CompEx: novel exacerbation measure may speed up asthma drug development' by clicking on the link below.

Published:

The Lancet Respiratory Medicine, published online ahead of print1 June 2017, DOI:http://dx.doi.org/10.1016/S2213-2600(17)30218-7

Author(s):

Da Silva, Carla; Fagerås, Malin; Johnson, Anthony Show all authors Jauhiainen, Alexandra; Sethi, Tariq

Early Discovery

11 May 2017 Details

Published:

Clinical Microbiology Reviews, published online ahead of print 11 May 2017, DOI: 10.1128/CMR.00111

Author(s):

Sjö, Peter

Early Discovery

10 May 2017 Details

Please read the related article 'Revealing the dynamic structure of ATM' by clicking on the link below.

Published:

Science Advances 10 May 2017: Vol. 3, no. 5, e1700933 DOI: 10.1126/sciadv.1700933

Author(s):

Phillips, Christopher Show all authors Fisher, David; Pollard, Hannah K; Truman, Caroline M

Revealing the dynamic structure of ATM

Oncology

10 May 2017 Details

Published:

Journal of Clinical Oncology - published online ahead of print May 10, 2017 DOI: 10.1200/JCO.2017.73.0143

Author(s):

Lindemann, Justin PO; Ambrose, Helen J; Schiavon, Gaia Show all authors Barrett, Carl; Dougherty, Brian; Foxley, Andrew; McEwen, Robert; Pass, Martin

Early Discovery

26 April 2017 Details

Please read the related article 'New structural insight into the highly challenging drug target PAR2 helps paves the way for future therapies in inflammatory pain' by clicking on the link below.

Published:

Nature, published online 26 April 2017 DOI: 10.1038/nature22309

Author(s):

Dekker, Niek; Edman, Karl; Geschwinder, Stefan Show all authors Hermansson, Nils-Olov; Johansson, Patrik; Snijder, Arjan; Sundström, Linda; Brown, Dean G; Grebner, Christoph; Thornton, Peter

Early Clinical Development

03 April 2017 Details

Published:

The Lancet, published online 3 April 2017 DOI: http://dx.doi.org/10.1016/S0140-6736(17)30823-1

Author(s):

Webber, Lorraine

CVRM

22 February 2017 Details

Please read the related article 'Early intervention for pre-diabetes shown to prevent long-term complications' by clicking on the link below.

Published:

The Lancet (2017) Published online 22 February 2017 doi:10.1016/S2213-8587(17)30061-X

Author(s):

Carlsson, Björn; Karlsson, Cecilia

Early intervention for pre-diabetes shown to prevent long-term complications

Respiratory

06 February 2017 Details

Published:

Nature Genetics (2017) Published online 06 February 2017 doi:10.1038/ng.3752

Author(s):

Rennard, Stephen I; Hardin, Megan

Early Discovery

09 January 2017 Details

Published:

Nature Chemical Biology (2017) Published online 09 January 2017 DOI:10.1038/nchembio.2270

Author(s):

Johansson, Patrik Show all authors Hongming Chen, Margareta E Ek, Arjan Snijder

Publications

Commitment to science

Our commitment to science is reflected in our track record of publications. Here are a few recent examples of high impact publications co-authored by AstraZeneca scientists.