Gastrointestinal

Patient Reported Outcomes

RESQ-7 (Reflux Symptom Questionnaire, 7 day recall)

The RESQ-7 is a 13-item reliable and valid questionnaire measuring gastroesophageal reflux disease symptoms: Heartburn (5 items), Regurgitation (4 items), Cough, difficulty swallowing, hoarseness (3 items), Burping (1 item). The RESQ-7 has shown high inter-item correlation (alpha = 0.77–0.87 for intensity and 0.72–0.82 for frequency). Test–retest reliability was good or excellent (0.70–0.78 for intensity and 0.65–0.75 for frequency).

  • Developed for paper administration
  • Takes approx 2-4 minutes to complete
  • Recall period is last seven days
  • Each item is rated on a 6-point Likert scale
  • Developed for adult patients with a partial response to PPI treatment

References:

Rydén A, Denison H, Karlsson M, Vakil N. Development and validation of a patient-reported outcome instrument in partial responder to proton pump inhibitor. Scand J Gastroenterol 2013, doi: 10.3109/00365521.2013.822544

Vakil N, Björck K, Denison H, Halling K, Karlsson M, Paty J, Silberg D, Rydén A. Validation of the Reflux Symptom Questionnaire Electronic Diary in partial responder to proton pump inhibitor. CTG 2012:3, e7;doi:10.1038/ctg.2012.1

Vakil N, Karlsson M, Denison H, Rydén A. A patient reported outcome instrument in partial responders to proton pump inhibitor therapy suggests new symptoms deserve consideration: Results from a validation study. Gut 2011;60 (Suppl 3), A266

Vakil N, Karlsson M, Denison H, Rydén A. The development of a patient reported outcome instrument in partial responders to proton pump inhibitor therapy suggests new symptoms deserve consideration: Results of a validation study. Gastroenterol 2011;140(5) (Suppl 1), P S-67

RESQ-eD (Reflux Symptom Questionnaire e-Diary)

The RESQ-eD7 is an electronic version of the RESQ-7. RESQ-eD has 13 items, it is a reliable and valid questionnaire measuring gastroesophageal reflux disease symptoms: Heartburn (5 items), Regurgitation (4 items), Cough, difficulty swallowing, hoarseness (3 items), Burping (1 item). Patients are asked to report twice daily, once in the morning and once before going to bed. The RESQ-eD has shown high inter-item correlation (alpha = 0.87–0.95). Test–retest reliability was good or excellent (0.65–0.85).

  • Developed for electronic, daily administration
  • Takes approx 3-5 minutes to complete
  • Combined into a 24 hour recall
  • Each item is rated on a 6-point Likert scale
  • Developed for adult patients with a partial response to PPI treatment

References:

Vakil N, Björck K, Denison H, Halling K, Karlsson M, Paty J, Silberg D, Rydén A. Validation of the Reflux Symptom Questionnaire Electronic Diary in partial responder to proton pump inhibitor. CTG 2012:3, e7;doi:10.1038/ctg.2012.1

Rydén A, Denison H, Karlsson M, Vakil N. Development and validation of a patient-reported outcome instrument in partial responder to proton pump inhibitor. Scand J Gastroenterol 2013, doi: 10.3109/00365521.2013.822544

Vakil N, Karlsson M, Denison H, Rydén A. A patient reported outcome instrument in partial responders to proton pump inhibitor therapy suggests new symptoms deserve consideration: Results from a validation study. Gut 2011;60 (Suppl 3), A266

Vakil N, Karlsson M, Denison H, Rydén A. The development of a patient reported outcome instrument in partial responders to proton pump inhibitor therapy suggests new symptoms deserve consideration: Results of a validation study. Gastroenterol 2011;140(5) (Suppl 1), P S-67

GSRS (Gastrointestinal Symptom Rating Scale)

The GSRS is a disease-specific instrument. The 15 items combine into five symptom clusters: Reflux, Abdominal pain, Indigestion, Diarrhoea and Constipation. The reliability and validity of the GSRS are well-documented, and norm values for a general population are available. The original questionnaire is an interview-based rating scale but has been modified to become a self administered questionnaire. There are specific instructions for the IBS version.

  • Developed for paper administration
  • Takes approximately 3-5 minutes
  • Recall period is past week
  • Each item is rated on a 7-point Likert scale
  • Developed for adult patients with irritable bowel syndrome (see also GSRS IBS) and peptic ulcer disease

References:

Svedlund J, Sjödin I, Dotevall G. GSRS - A clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci 1988; 33:129-134.

Dimenäs E, Glise H, Hallerbäck B, Hernqvist H, Svedlund J, Wiklund I. Quality of life in patients with upper gastrointestinal symptoms. An improved evaluation of treatment regimens? Scand J Gastroenterol 1993; 28:681-687.

Dimenäs E, Glise H, Hallerbäck B, Hernqvist H, Svedlund J, Wiklund I. Well-being and gastrointestinal symptoms among patients referred to endoscopy owing to suspected duodenal ulcer. Scand J Gastroenterol 1995; 30:1046-1052.

Kulich KR, Madisch A, Pacini F, Piqué JM, Regula J, Van Rensburg CJ, Újszászy L, Carlsson J, Halling K, Wiklund IK. Reliability and validity of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in dyspepsia: A six-country study. Health and Quality of Life Outcomes 2008, 6:12 doi:10.1186/1477-7525-6-12

GSRS IBS (Gastrointestinal Symptom Rating Scale)

The GSRS IBS is a 13-item reliable, valid and user-friendly instrument with excellent psychometric properties measuring. Depicting problems with satiety, abdominal pain, diarrhoea, constipation and bloating. The internal consistency reliability was high, ranging from 0.74 (pain) to 0.85 (satiety).

  • Developed for paper administration
  • Takes approximately 3-5 minutes
  • Recall period is past week
  • Each item is rated on a 7-point Likert scale
  • Developed for adult patients with irritable bowel syndrome

References:

Wiklund I, Fullerton S, Hawkey CJ, Jones RH, Longstreth GF, Mayer EA, Peacock RA, Wilson IK, Naesdal J. An irritable bowel syndrome-specific symptom questionnaire: development and validation. Scand J Gastroenterol 2003; 38(9):947-54

QOLRAD (Quality of life in reflux and dyspepsia)

The QOLRAD is a 25 item user-friendly instrument depicting problems with emotions, vitality, sleep, eating/drinking, and physical/social functioning. It has shown excellent psychometric properties with high internal consistency reliability (0.70 – 0-92) and goodness of fit of the five-factor solution ranged between 0.77 – 0.91. There are specific instructions for respective instrument version for RI, chestpain, dyspepsia, heartburn and NSAID.

  • Developed for paper administration
  • Takes approximately 5-7 minutes
  • Recall period is past week
  • Each item is rated on a 7-point Likert scale
  • Developed for adult patients with reflux disease

References:

Wiklund IK, Junghard O, Grace E, et al. Quality of life in reflux and dyspepsia patients. Psychometric documentation of a new disease-specific questionnaire (QOLRAD). Eur J Surg 1998;164(suppl 583):41–9.

Talley NJ, Fullerton S, Junghard O, Wiklund I. Quality of life in patients with endoscopy-negative heartburn: Reliability and sensitivity of disease-specific instruments. Am J Gastroenterol 2001; 96(7): 1998–2004.

Kulich KR, Wiklund I, Junghard O. Factor structure of the Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire evaluated in patients with heartburn predominant reflux disease. Quality of Life Research 2003; 12:699–708.

Kulich KR, Madisch A, Pacini F, Piqué JM, Regula J, Van Rensburg CJ, Újszászy L, Carlsson J, Halling K, Wiklund IK. Reliability and validity of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in dyspepsia: A six-country study. Health and Quality of Life Outcomes 2008, 6:12 doi:10.1186/1477-7525-6-12

TSQG (Treatment Satisfaction Questionnaire - GERD)

The TSQG is a 28-item reliable, valid and user-friendly instrument with good psychometric properties It consists of 7 domains: Symptoms; Satisfaction; Flexibility with dosing (pro re nata, PRN); Expectations, Cost; Provider relationships (MD); Bother. The internal consistency reliability was moderate to high, ranging from 0.59 (MD) to 0.94 (Symptoms).

  • Developed for paper administration
  • Takes approximately 3-5 minutes
  • Recall period is past 2 week
  • Each item is rated on a 6-point Likert scale
  • Developed for adult patients with GERD

References:

Coyne KS, Wiklund I, Schmier J, Halling K, Degl’Innocenti A, Revicki D. Development and validation of a disease-specific satisfaction questionnaire for gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2003; 18:907-15.

RDQ (Reflux disease questionnaire)

RDQ (Reflux disease questionnaire)

The RDQ is a 12-item questionnaire designed to assess the frequency and severity of heartburn, regurgitation, and dyspeptic complaints and to facilitate the diagnosis of GERD in primary care. No sample instrument to view.

•    Developed for paper administration

•    Takes approximately 3-5 minutes

•    Recall period is last 7 days

•    Each item is rated on a 6-point Likert scale

•    Developed for adult patient with reflux disease

References:

Shaw MJ, Talley NJ, Beebe TJ, Rockwood T, Carlsson R, Adlis S, Fendrick M, Jones R, Dent J, Bytzer P. Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroentereol 2001; 96(1):52-57.
Aanen MC, Numans ME, Weusten BLAM, Smout AJPM. Diagnostic value of the Reflux Disease
Questionnaire in general practice. Digestion 2006;74:162–168. DOI: 10.1159/000100511

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